- Enantioselective synthesis of a taxol C ring
-
An enantioselective synthesis of a C ring of taxol has been accomplished. The key step is an oxidative cleavage of a derivative of the Wieland-Miescher ketone. A first attempt of a Shapiro reaction modelling the coupling of the C ring with the A fragment of taxol was also successful.
- Ma, Cong,Schiltz, Stephanie,Prunet, Joelle
-
experimental part
p. 1579 - 1594
(2012/05/19)
-
- Selective allylic hydroxylation of octahydronaphthalene derivatives with a bridgehead double bond using electrochemical method with iron picolinate complexes
-
The combination of electrolysis and the FeIII(PA) 3/O2/CH3CN system was investigated for allylic hydroxylation of octahydronaphthalene derivatives. Substrates with a bridgehead double bond gave the allylic alcohol with α-preference, while non-bridgehead olefin did not react smoothly. This system is a useful tool for α-selective allylic hydroxylation of octahydronaphthalene derivatives with a bridgehead double bond as model compounds for the AB fused ring of cholesterols.
- Okamoto, Iwao,Funaki, Wataru,Nobuchika, Sachiyo,Sawamura, Mika,Kotani, Eiichi,Takeya, Tetsuya
-
p. 248 - 252
(2007/10/03)
-
- Total synthesis of (-)-hispanolone and an improved approach towards prehispanolone
-
On the basis of the recently reported construction of (±)-hispanolone (2), the enantiomerically pure form of (-),2, employed in our partial synthesis of the specific platelet activating factor receptor antagonist prehispanolone (3), was prepared from (S)-
- Cheung, Wing Shun,Wong, Henry N. C.
-
p. 11001 - 11016
(2007/10/03)
-
- An Enantioselective Total Synthesis of (+)-Atisirene by Intramolecular Double Michael Reaction
-
1,6-Conjugate addition of 2-methoxybenzylmagnesium bromide to 4-methylene-3,5,5-trimethylcyclohex-2-enone (7), followed by hydrocyanation, gave (+/-)-(1RS,2SR)-2--1,3,3-trimethyl-5-oxocyclohexanecarbonitrile (9), which was conver
- Ihara, Masataka,Toyota, Masahiro,Fukumoto, Keiichiro,Kametani, Tetsuji
-
p. 2151 - 2162
(2007/10/02)
-