321532-05-2Relevant articles and documents
Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists
Evans, Karen A.,Budzik, Brian W.,Ross, Sean A.,Wisnoski, David D.,Jin, Jian,Rivero, Ralph A.,Vimal, Mythily,Szewczyk, George R.,Jayawickreme, Channa,Moncol, David L.,Rimele, Thomas J.,Armour, Susan L.,Weaver, Susan P.,Griffin, Robert J.,Tadepalli, Sarva M.,Jeune, Michael R.,Shearer, Todd W.,Chen, Zibin B.,Chen, Lihong,Anderson, Donald L.,Becherer, J. David,De Los Frailes, Maite,Colilla, Francisco Javier
supporting information; experimental part, p. 7962 - 7965 (2010/07/13)
A series of 3-aryl-4-isoxazolecarboxamides identified from a high-throughput screening campaign as novel, potent small molecule agonists of the human TGR5 G-protein coupled receptor is described. Subsequent optimization resulted in the rapid identificatio