321726-55-0

Basic information

• Product Name: 4-FORMYLPHENYL 2-CHLOROBENZOATE
• Synonyms: 4-FORMYLPHENYL 2-CHLOROBENZOATE;(4-methanoylphenyl) 2-chlorobenzoate;2-chlorobenzoic acid (4-formylphenyl) ester;2-Chloro-benzoic acid 4-formyl-phenyl ester;BAS 00319281;Benzoic acid, 2-chloro-, 4-formylphenyl ester;SBB005043;ZINC00242209
• CAS NO: 321726-55-0
• Molecular Formula: C₁₄H₉ClO₃
• Molecular Weight: 260.68
• Mol File: 321726-55-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-FORMYLPHENYL 2-CHLOROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FORMYLPHENYL 2-CHLOROBENZOATE(321726-55-0)
• EPA Substance Registry System: 4-FORMYLPHENYL 2-CHLOROBENZOATE(321726-55-0)

Safety Data

• Hazardous Substances Data: 321726-55-0(Hazardous Substances Data)

Upstream product

• 609-65-4 o-chlorobenzoyl chloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 708263-37-0 Z-5-[4-(2-chlorobenzoyloxy)benzylidene]-2-thiohydantoin 

Relevant articles and documents

Design, synthesis and evaluation of rhodanine derivatives as aldose reductase inhibitors

Aldose reductase (ALR) enzyme plays a significant role in conversion of excess amount of glucose into sorbitol in diabetic condition, inhibitors of which decrease the secondary complication of diabetes mellitus. To understand the structural interaction of inhibitors with ALR enzyme and develop more effective ALR inhibitors, a series of substituted 5-phenylbenzoate containing N-substituted rhodanine derivatives were synthesized and evaluated for their in vitro ALR inhibitory activity. Docking studies of these compounds were carried out, which revealed that the 5-phenylbenzoate moiety deeply influenced the key π-π stacking while 4-oxo-2-thioxothiazolidines contributed in hydrogen bond interactions. The phenyl ring of benzylidene system occupied in specific pocket constituted from Phe115, Phe122, Leu300 and Cys303 while the rhodanine ring forms a tight net of hydrogen bond with Val47 at anionic binding site of the enzyme. The structural insights obtained from the docking study gave better understanding of rhodanine and macromolecular interaction and will help us in further designing and improving of ALR inhibitory activity of rhodanine analogs. Series of substituted 5-phenylbenzoate rhodanine analogs were synthesized and evaluated for their ALR inhibitory activity. The docking study of synthesized compounds was carried out, which revealed that the 5-phenylbenzoate moiety deeply influenced the key π-π stacking while 4-oxo-2-thioxothiazolidines contributed in hydrogen bond interactions.

Imidazo[2,1-b]thiazepines: Synthesis, structure and evaluation of benzodiazepine receptor binding

As a continuation of our search for new ligands acting on benzodiazepine receptors among the fused 2-thiohydantoin derivatives, a series of 5-substituted imidazo[2,1-b]thiazepines was synthesized and investigated in radioligand binding studies at the benz