- Synthetic, structural mimetics of the β-hairpin flap of HIV-1 protease inhibit enzyme function
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Small-molecule mimetics of the β-hairpin flap of HIV-1 protease (HIV-1 PR) were designed based on a 1,4-benzodiazepine scaffold as a strategy to interfere with the flap-flap protein-protein interaction, which functions as a gated mechanism to control acce
- Chauhan, Jay,Chen, Shen-En,Fenstermacher, Katherine J.,Naser-Tavakolian, Aurash,Reingewertz, Tali,Salmo, Rosene,Lee, Christian,Williams, Emori,Raje, Mithun,Sundberg, Eric,Destefano, Jeffrey J.,Freire, Ernesto,Fletcher, Steven
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p. 7095 - 7109
(2015/11/11)
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- Orally active zwitterionic factor Xa inhibitors with long duration of action
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We have optimized 2-aminomethylphenylamine derivative as a factor Xa inhibitor. Several polar functional groups were introduced in the central phenyl ring, and we focused on zwitter ionic compound showing continuous inhibitory activity in oral administrat
- Mochizuki, Akiyoshi,Nagata, Tsutomu,Kanno, Hideyuki,Takano, Daisuke,Kishida, Masamichi,Suzuki, Makoto,Ohta, Toshiharu
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scheme or table
p. 7337 - 7343
(2012/02/04)
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- Selective colorimetric sensing of anions in aqueous media through reversible covalent bonding
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(Chemical Equation Presented) Selective colorimetric sensing of anions in aqueous media has been studied, which involves reversible covalent bonding as key binding interactions. By introducing a simple nitro chromophore into an o-(carboxamido)trifluoroace
- Kim, Dae-Sik,Chung, Yun-Mi,Jun, Mieun,Ahn, Kyo Han
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supporting information; experimental part
p. 4849 - 4854
(2009/10/09)
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- Bicyclic antagonists selective for the αvβ3 integrin
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This invention provides novel bicyclic compounds of Formula (I): wherein u, v, m, Y, G, A—B, R1, R1a, R2, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption and compounds of Formula (II) wherein u, v, m, Y, G, D, A—B, R1, R1a, R2, R3, R4, R5, R5a, and R5b are defined in the specification which compounds exhibit activity as inhibitors of bone resorption.
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