N-substituted 2-amino-4-pentenoic acids for amino acid protection and resolution
N-Substituted 2-amino-4-pentenoic acid derivatives employed for the protection of racemic amino acids were shown to be capable of permitting the chromatographic separation of R and S isomers. When N(α) was disubstituted with benzyl and phenylfluorenyl groups, the racemic amino acids could be separated with facility on open silica gel columns. Further, the optically pure N-protected amino acids so derived could be used for the preparation of misacylated suppressor transfer RNAs. (C) 2000 Elsevier Science Ltd.
Lodder, Michiel,Wang, Bixun,Hecht, Sidney M.
p. 9421 - 9429
(2007/10/03)
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