32384-59-1

The invention discloses a preparation method and post-treatment method for a trimethylsilyl protecting group of a polyhydroxy carbohydrate compound. According to the preparation method, a reaction occurs by taking the polyhydroxy carbohydrate compound as a raw material, dichloromethane, tetrahydrofuran, methylbenzene and methyl tert-butyl ether as solvents and a halogen elementary substance or a halogen-containing trimethyl reagent as a catalyst; then a protecting group compound is added, and the temperature is controlled to be 0-60 DEG C; and finally, an adsorbent is added into a reaction solution, and filtering is performed to obtain the product. The simple-to-operate preparation method for the trimethylsilyl protecting groups on polyhydroxy saccharide and a polyhydroxy natural product has the advantages that the raw and auxiliary materials are few; the cost is low; post-treatment is simple; a way of post-treatment with water is avoided; and the used catalyst is completely removed byadopting the multi-pore activated carbon and multi-pore ion resin, thus guaranteeing the stability increase of the product.