Hydrazones as novel epigenetic modulators: Correlation between TET 1 protein inhibition activity and their iron(II) binding ability
Ten-eleven translocation protein (TET) 1 plays a key role in control of DNA demethylation and thereby of gene expression. Dysregulation of these processes leads to serious pathological states such as oncological and neurodegenerative ones and thus TET 1 t
Jakubek, Milan,Kejík, Zdeněk,Kaplánek, Robert,Antonyová, Veronika,Hromádka, Róbert,?andriková, Viera,Sykora, David,Martásek, Pavel,Král, Vladimír