cas 324763-47-5, BenzeneoctanaMide, N-(3-aMino-2,2-diMethyl-3-oxopropyl)- δ-azido-γ-hydroxy-4-Methoxy-3-(3-Methoxypropoxy)- α, ζ-bis(1-Methylethyl)-, (αS, γS, δS, ζS)-

Articles about 324763-47-5Total 7 be found

A Total synthesis of aliskiren starting from D-Tartrate diester
A formal total synthesis of aliskiren was accomplished. A key in our synthesis was to use the symmetric ciscisoid-Cis-Bis-Lactone 3' as a precursor, which was prepared from D-tartrate diester. Appending the end groups and functional group transformations completed the synthesis.
Kim, Ji Hei,Ko, Soo Y.
p. 3777 - 3781
(2014/01/17)

PROCESS FOR THE PREPARATION OF ALISKIREN
The present invention relates to an improved process for the preparation of Aliskiren and its pharmaceutically acceptable salts comprising reducing the compound of Formula-Z in presence of catalyst and ammonia. The present invention further relates to Aliskiren hemifumarate having diastereomeric impurity less than 0.2%.(F) H3C CH3 NH2 H3C 0 H3C CH3 Formula-Z
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(2013/10/21)

SYNTHESIS OF ALISKIREN
The present invention provides novel process for the preparation of renin inhibitor Aliskiren or its derivatives, and its pharmaceutically acceptable salts. The present invention also provides novel intermediates used in the preparation of Aliskiren.
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Page/Page column 16

(2012/05/05)

PROCESS FOR THE PREPARATION OF (2S,4S,5S,7S)-N-(2-CARBAMYL-2- METHYLPROPYL)-5-AMINO-4-HYDROXY-2,7-DIISOPROPYL-8-[4-METHOXY-3-(3- METHOXYPROPOXY)PHENYL]-OCTANAMIDE HEMIFUMARATE AND ITS INTERMEDIATES THEREOF
The present invention relates to a process for the preparation of (2S,4S,5S,7S)-N-(2- Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxy propoxy )phenyl]-octanamide compound of formula- 1 and its pharmaceutically acceptable salts thereof. Further, relates to the processes for the preparation of (R)-4-(2-(halomethyl)-3- methylbutyl)-l-methoxy-2-(3-methoxypropoxy) benzene and (R)-2-(4-methoxy-3-(3-methoxy propoxy) benzyl)-3-methyIbutan-l-ol useful intermediates in the synthesis of compound of formula- 1.
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(2011/12/14)

AMIDE INHIBITORS OF RENIN
The present invention relates to new amide inhibitors of renin, pharmaceutical compositions thereof, and methods of use thereof
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(2010/06/13)

A convergent synthesis of the renin inhibitor CGP60536B
Pseudoephedrine serves as a dual purpose chiral auxiliary and protecting group in the synthesis of the novel orally active renin inhibitor CGP60536B. (C) 2000 Elsevier Science Ltd.
Sandham,Taylor,Carey,Fassler
p. 10091 - 10094
(2007/10/03)

A convergent synthesis approach towards CGP60536B, a non-peptide orally potent renin inhibitor, via an enantiomerically pure ketolactone intermediate
We report a convergent synthesis of the potent orally active non-peptide renin inhibitor CGP60536B. The key reaction employs the coupling of the enantiopure Grignard species derived from chloride 13 with the diastereomerically pure γlactone 9b. The stereoselective reduction of the resulting ketone 14b has been thoroughly investigated. (C) 2000 Elsevier Science Ltd.
Rueger,Stutz,Goschke,Spindler,Maibaum
p. 10085 - 10089
(2007/10/03)