32511-63-0

Basic information

• Product Name: 1,25-DIHYDROXYVITAMIN D3
• Synonyms: 1,25-DIHYDROXYVITAMIN D3;(5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3β,25-triol
• CAS NO: 32511-63-0
• Molecular Formula: C₂₇H₄₄O₃
• Molecular Weight: 416.64
• Mol File: 32511-63-0.mol

Chemical Properties

• Boiling Point: 565°Cat760mmHg
• Flash Point: 238.4°C
• Appearance: /
• Density: 1.06g/cm³
• Vapor Pressure: 4.05E-15mmHg at 25°C
• Refractive Index: 1.547
• PKA: 14.43±0.40(Predicted)
• CAS DataBase Reference: 1,25-DIHYDROXYVITAMIN D3(CAS DataBase Reference)
• NIST Chemistry Reference: 1,25-DIHYDROXYVITAMIN D3(32511-63-0)
• EPA Substance Registry System: 1,25-DIHYDROXYVITAMIN D3(32511-63-0)

Safety Data

• Hazardous Substances Data: 32511-63-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,25-DIHYDROXYVITAMIN D3 is used as a therapeutic agent for the treatment of conditions related to calcium and phosphorus metabolism, such as osteoporosis, kidney disease, and hypocalcemia. It helps in maintaining optimal calcium and phosphorus levels in the body, promoting bone health and preventing bone loss.
Used in Nutritional Supplements:
1,25-DIHYDROXYVITAMIN D3 is used as a dietary supplement to support bone health and overall well-being. It helps in maintaining adequate vitamin D levels in individuals who may be at risk of deficiency due to limited sun exposure, poor diet, or certain medical conditions.
Used in Research and Development:
1,25-DIHYDROXYVITAMIN D3 is used as a research tool in the study of vitamin D metabolism, its role in various health conditions, and the development of new therapeutic agents targeting vitamin D receptors. It aids in understanding the molecular mechanisms underlying the hormone's effects on calcium and phosphorus regulation, immune system modulation, and its potential in treating diseases such as cancer.
Used in Immunomodulation and Anti-Inflammatory Applications:
1,25-DIHYDROXYVITAMIN D3 is used as an immunomodulatory and anti-inflammatory agent, playing a role in the regulation of the immune system. It has been studied for its potential in treating autoimmune diseases and inflammatory conditions by modulating immune cell activity and reducing inflammation.
Used in Cancer Research and Treatment:
1,25-DIHYDROXYVITAMIN D3 is used as a potential therapeutic agent in cancer research and treatment. It has been studied for its ability to inhibit cancer cell growth, induce cell differentiation, and promote cell death. Additionally, it has been investigated for its potential synergistic effects with conventional cancer therapies, enhancing their efficacy and reducing side effects.

InChI:InChI=1/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25?,27-/m1/s1

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Relevant articles and documents

Investigation of Vitamin D2 and Vitamin D3 Hydroxylation by Kutzneria albida

The active vitamin D metabolites 25-OH?D and 1α,25-(OH)2?D play an essential role in controlling several cellular processes in the human body and are potentially effective in the treatment of several diseases, such as autoimmune diseases, cardiovascular diseases and cancer. The microbial synthesis of vitamin D2 (VD2) and vitamin D3 (VD3) metabolites has emerged as a suitable alternative to established complex chemical syntheses. In this study, a novel strain, Kutzneria albida, with the ability to form 25-OH?D2 and 25-OH?D3 was identified. To further improve the conversion of the poorly soluble substrates, several solubilizers were tested. 100-fold higher product concentrations of 25-OH?D3 and tenfold higher concentrations of 25-OH?D2 after addition of 5 % (w/v) 2-hydroxypropyl β-cyclodextrin (2-HPβCD) were reached. Besides the single-hydroxylation products, the human double-hydroxylation products 1,25-(OH)2?D2 and 1,25-(OH)2?D3 and various other potential single- and double-hydroxylation products were detected. Thus, K. albida represents a promising strain for the biotechnological production of VD2 and VD3 metabolites.