325705-48-4

Basic information

• Product Name: Pentonic acid, 3-amino-2,3,5-trideoxy-5-fluoro- (9CI)
• Synonyms: Pentonic acid, 3-amino-2,3,5-trideoxy-5-fluoro- (9CI)
• CAS NO: 325705-48-4
• Molecular Formula: C5H10FNO3
• Molecular Weight: 0
• Mol File: 325705-48-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pentonic acid, 3-amino-2,3,5-trideoxy-5-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pentonic acid, 3-amino-2,3,5-trideoxy-5-fluoro- (9CI)(325705-48-4)
• EPA Substance Registry System: Pentonic acid, 3-amino-2,3,5-trideoxy-5-fluoro- (9CI)(325705-48-4)

Safety Data

• Hazardous Substances Data: 325705-48-4(Hazardous Substances Data)

Upstream product

• 204919-53-9 tert-butyl 3-nitropropionate 
• 161401-78-1 t-butyl 5-fluoro-4-hydroxy-3-nitropentanoate 

Downstream Products

• 243857-28-5 Z-[(S)-Phg]-Asp(Ot-Bu)-fmk 
• 582317-80-4 Z-Ile-Asp-fluoromethylketone 

Relevant articles and documents

Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: Peptidomimetic replacement of the P2 amino acid by 2-aminoaryl acids and other non-natural amino acids

As a continuation of our SAR studies of dipeptidyl aspartyl-fmk as caspase inhibitors, we explored the replacement of the P2 amino acid by a 2-aminoaryl acid or other non-natural amino acids. Several of these compounds, such as 6l and 6p, were

Design and synthesis of an affinity probe that targets caspases in proteomic experiments

The field of proteomics aims to study all proteins in the human proteome. This huge task may be accelerated by using active-site directed probes which profile proteins in an activity-dependent manner. Herein, we have developed a fluorescently-labeled affinity probe containing chemical reactivity specific towards caspases. Preliminary assays and proof-of-concept experiments demonstrated that this probe exhibits strong chemical reactivity towards caspase-1 over other enzymes, capable of covalently labeling caspapse-1 over other non-caspase enzymes. This thus demonstrates its selectivity and potential in high-throughput screenings of other unknown caspases in a large-scale proteomics experiment.

Dipeptide apoptosis inhibitors and the use thereof

The present invention is directed to novel dipeptides thereof, represented by the general Formula I: where R1-R3 and AA are defined herein. The present invention relates to the discovery that compounds having Formula I are potent inhibitors of apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.

Synthesis of P1 Aspartate-Based Peptide Acyloxymethyl and Fluoromethyl Ketones as Inhibitors of Interleukin-1β-Converting Enzyme

Improved procedures have been developed for the synthesis of P1 aspartate-based 2,6-dichlorobenzoyloxymethyl ketone 1 and fluoromethyl ketone 2, the prodrugs of two potent ICE-inhibitors. 1 was prepared from (R)-trans-4,5-O-isopropylidene-4,5-dihydroxy-2-