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325746-94-9

5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione, also known as BPIPP, is a chemical compound that acts as a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor. It has potential therapeutic applications due to its ability to inhibit cGMP synthesis induced by stable toxin a (STa).

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  • 325746-94-9 Structure

  • Basic information

    1. Product Name: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione
    2. Synonyms: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione;BPIPP
    3. CAS NO:325746-94-9
    4. Molecular Formula: C22H16BrN3O3
    5. Molecular Weight: 450
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 325746-94-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Store at RT
    8. Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
    9. Stability: Air Sensitive
    10. CAS DataBase Reference: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione(325746-94-9)
    12. EPA Substance Registry System: 5-(3-Bromophenyl)-5,11-dihydro-1,3-dimethyl-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione(325746-94-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 325746-94-9(Hazardous Substances Data)

325746-94-9 Usage

Uses

Used in Pharmaceutical Industry:
BPIPP is used as a potential treatment for diarrhea caused by the inhibition of stable toxin a (STa)-induced cGMP synthesis. Its ability to act as a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor makes it a promising candidate for the development of new therapeutic agents to combat diarrhea and related gastrointestinal disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 325746-94-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,5,7,4 and 6 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 325746-94:
(8*3)+(7*2)+(6*5)+(5*7)+(4*4)+(3*6)+(2*9)+(1*4)=159
159 % 10 = 9
So 325746-94-9 is a valid CAS Registry Number.

325746-94-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name ST50103571

1.2 Other means of identification

Product number -
Other names BPIPP

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:325746-94-9 SDS

325746-94-9Downstream Products

325746-94-9Relevant articles and documents

Novel pyridopyrimidine derivatives as inhibitors of stable toxin a (STa) induced cGMP synthesis

Tanifum, Eric A.,Kots, Alexander Y.,Choi, Byung-Kwon,Murad, Ferid,Gilbertson, Scott R.

supporting information; experimental part, p. 3067 - 3071 (2010/01/16)

A series of pyridopyrimidine derivatives were synthesized and evaluated for their ability to inhibit cyclic nucleotide synthesis in the presence of stable toxin a of Escherichia coli. The structure activity relationships around the basic core structure we

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