- Novel nucleoside analogues: First synthesis of pyridine-4-thioglycosides and their cytotoxic evaluation
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The reaction of sodium 2,2-dicyanoethene-1,1-bis(thiolate) with 2-cyano-N-arylacetamides afforded sodium pyridine-4-thiolates, coupling of the latters with 2,3,4,6-tetra-O-acetyl-D-gluco- and D-galactopyranosyl bromides, respectively, afforded new pyridine-4-thioglycosides. Ammonolysis of the latter compounds afforded the free thioglycosides. The antitumor activities of the synthesized compounds were tested against human tumor cell lines; lung (A549), colon (HCT116), liver (HEPG2), and prostate (PC3).
- Elgemeie, Galal,Abou-Zeid, Mamdouh,Alsaid, Shahinaz,Hebishy, Ali,Essa, Hanaa
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p. 659 - 673
(2015/11/09)
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- Novel 1,3-dithiolan-2-ones using sodium α-cyanoketene dithiolates
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A novel and efficient method for the synthesis of 1,3-dithiolan-2-ones using sodium α-cyanoketene dithiolates and monochloroacetic acid as starting components is described. Copyright Taylor & Francis Group, LLC.
- Elgemeie,Elghandour,Elzanaty,Ahmed
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p. 755 - 764
(2007/10/03)
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- Synthesis of novel derivatives of 4-methylthio-N-aryl-2-pyridone and deazapurine analogues: The reaction of ketene dithioacetals with substituted acetanilides
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A new one-pot synthesis of 4-methylthio-N-aryl-2-pyridones and their deazapurine analogues by the reaction of ketene dithioacetals with substituted acetanilides have been reported.
- Elgemeie, Galal H.,Ali, Hosny A.,Elghandour, Ahmed H.,Abd Elaziz, Ghada W.
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p. 189 - 197
(2007/10/03)
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