326886-31-1

Basic information

• Product Name: 5-(3-ethoxy-4-hydroxybenzylidene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
• Synonyms: 5-(3-ethoxy-4-hydroxybenzylidene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione;5-(3-ethoxy-4-hydroxybenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
• CAS NO: 326886-31-1
• Molecular Formula: C₁₅H₁₆N₂O₅
• Molecular Weight: 304.29794
• Mol File: 326886-31-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(3-ethoxy-4-hydroxybenzylidene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-ethoxy-4-hydroxybenzylidene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione(326886-31-1)
• EPA Substance Registry System: 5-(3-ethoxy-4-hydroxybenzylidene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione(326886-31-1)

Safety Data

• Hazardous Substances Data: 326886-31-1(Hazardous Substances Data)

Upstream product

• 121-32-4 4-hydroxy-3-ethoxybenzaldehyde 
• 769-42-6 1,3-dimethylbarbituric acid 

Relevant articles and documents

5-Arylidene N,N-dimethylbarbiturates as urease inhibitors

Earlier 5-arylidene N,N-dimethylbarbiturates 1-24 were reported by our group as novel antioxidant, nevertheless, urease inhibitory activity of these compounds has not been investigated at all. In the present study, compounds 1-24 were synthesized by the reaction of N,N-dimethylbarbituric acid with different aromatic aldehydes, and screened for their in vitro urease inhibitory effects. Compound 7, was found to be most active urease inhibitor in the series. Nonetheless, compounds 11, 12, and 19 were also active against urease enzyme.

Xanthine oxidase inhibition by 5-aryledene N,N'-dimethylbarbituric acid derivatives

N,N'-dimethylbarbituric acid derivatives 1-24 were evaluated for their xanthine oxidase (XO) inhibitory activity. Majority of these compounds showed a good to moderate in vitro xanthine oxidase inhibitory activity (IC50 = 20.97 ± 0.29 - 327.0 ± 3.50 μM), while eight compounds were found to be completely inactive. A structure-activity relationship has been discussed, identifying structural features, responsible for varying degree of activity.

Synthesis and DPPH radical scavenging activity of 5-arylidene-N, Ndimethylbarbiturates

Twenty-four derivatives of N,N-dimethylbarbituric acid 1-24 were screened for their DPPH radical scavenging activity. These compounds showed an excellent antioxidant activity. A structure-activity relationship has been discussed, while all the synthetic compounds were characterized by spectroscopic techniques and elemental analysis.