326897-98-7

Basic information

• Product Name: Ethanone, 2,2,2-trifluoro-1-(3-hydroxyphenyl)- (9CI)
• Synonyms: Ethanone, 2,2,2-trifluoro-1-(3-hydroxyphenyl)- (9CI);2,2,2-trifluoro-1-(3-hydroxyphenyl)ethan-1-one
• CAS NO: 326897-98-7
• Molecular Formula: C8H5F3O2
• Molecular Weight: 190.1193096
• Product Categories: ACETYLHALIDE
• Mol File: 326897-98-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 2,2,2-trifluoro-1-(3-hydroxyphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2,2-trifluoro-1-(3-hydroxyphenyl)- (9CI)(326897-98-7)
• EPA Substance Registry System: Ethanone, 2,2,2-trifluoro-1-(3-hydroxyphenyl)- (9CI)(326897-98-7)

Safety Data

• Hazardous Substances Data: 326897-98-7(Hazardous Substances Data)

Upstream product

• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 30724-22-2 2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone 
• 23516-80-5 3-amino-α,α,α-trifluoroacetophenone 

Relevant articles and documents

Asymmetric synthesis of photophore-containing lactisole derivatives to elucidate sweet taste receptors

Lactisole, which has a 2-phenoxy propionic acid skeleton, is well-known as an inhibitor of sweet taste receptors. We recently revealed some of the structure-activity relationships of the aromatic ring and chiral center of lactisole. Photoaffinity labeling

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A copper-mediated trifluoroacetylation of various arenediazonium salts with ethyl trifluoropyruvate is reported. The reaction proceeded smoothly under mild conditions at room temperature giving trifluoromethyl aryl ketones in moderate to good yields. A variety of functional groups, including methoxy, hydroxy, ester, ketone, trifluoromethyl, and halide groups, were well tolerated. A possible reaction mechanism involving an aryl radical intermediate was proposed and supported by experimental evidence. This reaction provides a new route to trifluoromethyl aryl ketones, notable synthetic targets, from the corresponding anilines.

Structure-Activity Relations. Part 11. Biologically Active 2-Phenoxy-N-phenyl-3-pyridinecarboxamides: Potential Photoaffilnity Labels and Fused-ring Analogues

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