2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors
There is considerable interest in developing dopamine transporter (DAT) inhibitors as potential therapies for the treatment of cocaine abuse. We report herein our pharmacophore-based discovery and molecular modeling-assisted rational design of 2,3-disubst
Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors
The synthesis of 2-alkyl-3-aryl-substituted quinuclidines was accomplished in a simple synthetic sequence. The separation of enantiomers was carried out using chiral HPLC. (C) 2000 Elsevier Science Ltd.
Sakamuri,Enyedy,Kozikowski,Wang
p. 9949 - 9952
(2007/10/03)
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