Microwave-enhanced rhodium-catalyzed conjugate-addition of aryl boronic acids to unprotected maleimides
Various boronic acids were treated with a rhodium (I) catalyst enabling their 1,4-conjugate addition to unprotected maleimide. The scope of the reaction was explored to include both electron-rich and electron poor boronic acids. These reactions were also
Iyer, Pravin S.,O'Malley, Meaghan M.,Lucas, Matthew C.
p. 4413 - 4418
(2008/02/03)
Non-steroidal irreversible inhibitors of aromatase based on N-pentyl-3-phenylpyrrolidine-2,5-dione
1-Pentyl-3-(3'-propynyloxyphenyl) pyrrolidine-2,5-dione (20), its 3-propynyl substituted derivative (18), with its corresponding 4'-substituted isomer (21), constitute the first of a new type of non-steroidal mechanism-based inactivators of aromatase with