- A schub thiamine synthetic method
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The present invention provides a schub thiamine synthetic method, relates to the field of drug synthesis, comprising the following steps: (1) the disulphide thiamine, DMAP and organic solvent is added in the reaction bottle, and to control the temperature 20 - 30 °C, [...] anhydride, after dropping the condensation reaction, the reaction time is 1 - 3 h; (2) adding water to the reaction solution, washing, extraction, liquid, organic phase concentrated, after dissolving anhydrous ethanol, adding water crystallization 8 - 12 h, filtering, drying to constant weight to obtain the schub thiamine, with economically feasible, safety and environmental protection, high yield, and suitability for industrial production.
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Paragraph 0022-0027
(2018/07/30)
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