Discovery of triazines as potent, selective and orally active PDE4 inhibitors
Expanding on HTS hit 4 afforded a series of [1,3,5]triazine derivatives as novel PDE4 inhibitors. The SAR development and optimization process with the emphasis on ligand efficiency and physicochemical properties led to the discovery of compound 44 as a potent, selective and orally active PDE4 inhibitor.
Gewald, Rainer,Grunwald, Christian,Egerland, Ute
p. 4308 - 4314
(2013/07/25)
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