- A new and efficient route for the synthesis of naturally occurring catecholamines
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Catecholamines, sympathomimetic drugs and adrenergic receptor antagonists, have been prepared by a regioselective oxidation of the corresponding 4-hydroxyphenethylamine derivatives by 2-iodoxybenzoic acid (IBX) in homogeneous as well as in heterogeneous conditions and followed by cleavage of the amino protective group. By using polymer-supported IBX, after the first oxidation, the oxidant can be recovered, regenerated, and efficiently reused for several additional times. An efficient, easy and green procedure for the synthesis of N-(methoxycarbonyl)dopamine, key component of many pharmaceuticals, has also been reported. Georg Thieme Verlag Stuttgart.
- Bernini, Roberta,Crisante, Fernanda,Barontini, Maurizio,Fabrizi, Giancarlo
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experimental part
p. 3838 - 3842
(2010/03/30)
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