329-63-5

Basic information

• Product Name: DL-ADRENALINE HYDROCHLORIDE
• Synonyms: (±)-4-[1-hydroxy-2-(methylamino)ethyl]pyrocatechol hydrochloride;Adrenaline Hcl， racepinephrine hcl;1,2-Benzenediol, 4-1-hydroxy-2-(methylamino)ethyl-, hydrochloride;rs-epinephrine hcl;RACEPINEPHRINEHYDROCHLORIDE,USP;(±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride;(±)-Epirenamine hydrochloride;(±)-Epinephrine hydrochloride,(±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
• CAS NO: 329-63-5
• Molecular Formula: C₉H₁₃NO₃*ClH
• Molecular Weight: 219.67
• EINECS: 206-346-0
• Product Categories: API
• Mol File: 329-63-5.mol

Chemical Properties

• Melting Point: 157°
• Boiling Point: 413.1 °C at 760 mmHg
• Flash Point: 207.9 °C
• Appearance: solid
• Storage Temp.: 2-8°C
• Solubility: H2O: >50 mg/mL
• Stability: Stable, but light sensitive. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.
• Merck: 14,3619
• CAS DataBase Reference: DL-ADRENALINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-ADRENALINE HYDROCHLORIDE(329-63-5)
• EPA Substance Registry System: DL-ADRENALINE HYDROCHLORIDE(329-63-5)

Safety Data

• Hazard Codes: T
• Statements: 24/25-36/37/38
• Safety Statements: 26-36/37-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: DO3330000
• HazardClass: 6.1(a)
• PackingGroup: II
• Hazardous Substances Data: 329-63-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
DL-Adrenaline Hydrochloride is used as a bronchodilator for the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). It helps to relax the smooth muscles in the airways, allowing for easier breathing.
Used in Medical Research:
DL-Adrenaline Hydrochloride is used as an adrenergic receptor agonist in various research studies. It is used in the induction of renalase expression in human renal proximal tubular epithelial cells, which can help in understanding the role of renalase in kidney function and its potential therapeutic applications.
Used in Physiological Studies:
DL-Adrenaline Hydrochloride is used in infusion studies to test its effect on heart rate and eye temperature measurements in bulls. This helps researchers understand the physiological responses to adrenergic stimulation and its potential applications in veterinary medicine.
Used in Regenerative Medicine:
DL-Adrenaline Hydrochloride is used as a medium supplement for the stimulation of endothelial progenitor cells. This promotes the growth and differentiation of these cells, which are important for blood vessel formation and repair, and can have potential applications in tissue regeneration and wound healing.

Biochem/physiol Actions

Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility. It is used in the treatment of acute anaphylaxis. Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.

InChI:InChI=1/C9H13NO3.2ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;;/h2-4,9-13H,5H2,1H3;2*1H/p-1/t9-;;/m0../s1

Upstream product

• 87697-27-6 tert-butyl [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl](methyl)carbamate 

Relevant articles and documents

A new and efficient route for the synthesis of naturally occurring catecholamines

Catecholamines, sympathomimetic drugs and adrenergic receptor antagonists, have been prepared by a regioselective oxidation of the corresponding 4-hydroxyphenethylamine derivatives by 2-iodoxybenzoic acid (IBX) in homogeneous as well as in heterogeneous conditions and followed by cleavage of the amino protective group. By using polymer-supported IBX, after the first oxidation, the oxidant can be recovered, regenerated, and efficiently reused for several additional times. An efficient, easy and green procedure for the synthesis of N-(methoxycarbonyl)dopamine, key component of many pharmaceuticals, has also been reported. Georg Thieme Verlag Stuttgart.