329080-16-2

Basic information

• Product Name: 2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)SULFANYL]-N-[3-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE
• Synonyms: 2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)SULFANYL]-N-[3-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE
• CAS NO: 329080-16-2
• Molecular Formula: C₁₇H₁₂F₃N₃O₂S
• Molecular Weight: 379.36
• Mol File: 329080-16-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)SULFANYL]-N-[3-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)SULFANYL]-N-[3-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE(329080-16-2)
• EPA Substance Registry System: 2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)SULFANYL]-N-[3-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE(329080-16-2)

Safety Data

• Hazardous Substances Data: 329080-16-2(Hazardous Substances Data)

Usage

Appearance

White to off-white powder

Molecular weight

410.38 g/mol

Contains a sulfanyl group

Attached to an oxadiazole ring

Contains a trifluoromethyl group

Attached to a phenyl ring

Derivative of

Acetamide

Used in

Pharmaceutical and research applications

Specific properties and uses

Depend on the intended application in a particular context.

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 351-38-2 N-chloroacetyl-3-(trifluoromethyl)aniline 
• 3004-42-0 2-Mercapto-5-phenyl-1,3,4-oxadiazole 

Relevant articles and documents

Synthesis and evaluation of 2-(5-(aryl)-1,3,4-oxadiazol-2-ylthio)-N-(3- (trifluoromethyl)phenyl)acetamides and N-(4-chloro-3-fluorophenyl)-2-(5-(aryl)- 1,3,4-oxadiazol-2-ylthio)acetamides as antimicrobial agents

A series of 2-mercapto-5-phenyl-1,3,4-oxadiazole derivatives have been condensed with different phenyl acetamide derivatives possessing fluorine atom at meta position; resulting in the formation of 2-(5-aryl-1,3,4-oxadiazol-2- ylthio)-N-(3-(trifluoromethyl)phenyl)acetamide (5a-j) and N-(4-chloro-3- fluorophenyl)-2-(5-aryl-1,3,4-oxadiazol-2-ylthio)acetamide (5k-t) derivatives. The antimicrobial properties of the synthesized entities (5a-t) measured as their MIC (Minimum Inhibitory Concentration) values were evaluated by using the broth dilution method against Gram-positive bacteria (S. aureus and E. faecalis), Gram-negative bacteria (E. coli and P. aeruginosa) and fungi (C. albicans and A. niger). The results of antimicrobial activities (in μg/ml) revealed the fact that the compounds 5a and g bearing a maximum number of fluorine atoms showed the highest potency among the synthesized compounds against the broad panel of bacterial and fungal strains. The presence of fluorine atom at the meta position in the phenyl ring of final derivatives (5a-t) brought about an enhancement of their antimicrobial properties to a notable extent.