- "Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides
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(Figure Presented) Put the cassette in: An in situ enzymatic screen can give real-time estimates of the sense and magnitude of enantioselectivity across more than one substrate. Screening identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities. ADH = alcohol dehydrogenase, HL = horse liver, LK = Lactobacillus kefir, salen = (salicylidene) ethylenediamine.
- Dey, Sangeeta,Powell, Douglas R.,Hu, Chunhua,Berkowitz, David B.
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p. 7010 - 7014
(2008/09/17)
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- A new and improved process for celiprolol hydrochloride
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Celiprolol hydrochloride, a β-blocker drug, has been synthesized by a new approach. How this new process offers distinctive advantages over the existing one will be described.
- Joshi, Ramesh A.,Gurjar, Mukund K.,Tripathy, Narendra K.,Chorghade, Mukund S.
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p. 176 - 178
(2013/09/07)
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