- A competent synthesis and efficient anti-inflammatory responses of isatinimino acridinedione moiety via suppression of in vivo NF-κB, COX-2 and iNOS signaling
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A potent Nonsterodial Anti-inflammatory Drug (NSAID) candidates has been conceived and built by an assembly of a hydrophilic, fluorescent and COX-2 inhibiting units in the same molecule. The isatinimino-acridinedione core (TM-7) was achieved in a simple t
- Periyasami, Govindasami,Antonisamy, Paulrayer,Perumal, Karthikeyan,Stalin, Antony,Rahaman, Mostafizur,Alothman, Asma A.
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- Application of SiO 2 nanoparticles as an efficient catalyst to develop syntheses of perimidines and tetraketones
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Abstract: In this paper, we explore the catalytic activity of SiO 2 nanoparticles (NPs) as an eco-friendly, efficient and reusable catalyst in the synthesis of 2,3-dihydro-1H-perimidines as well as tetraketones. For tetraketones syntheses, a si
- Alinezhad, Heshmatollah,Ahmadi, Armin,Hajiabbasi, Parvin
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- Merging supramolecular catalysis and aminocatalysis: Amino-appended β-cyclodextrins (ACDs) as efficient and recyclable supramolecular catalysts for the synthesis of tetraketones
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Well-designed amino-appended β-cyclodextrins (ACDs) with an amino side chain of different lengths at the primary face of β-CD were synthesized and employed in the catalytic synthesis of a series of tetraketones as supramolecular catalysts in water for the first time. Yields of 58-97% were obtained with up to 30 examples of substrate. The catalyst could be recycled easily, while a 92% yield and 84% rate of catalyst recovery could be achieved after 8 cycles of catalyst recycling. Moreover, a catalytic mechanism merging supramolecular catalysis and aminocatalysis could be proposed through detailed 1D and 2D NMR, ESI-MS and Job plot analyses. This protocol retained the promising characteristics of ambient temperature, green medium, simple operation, broad substrate scope, excellent yields, superb catalyst recycling performance and unique catalytic mechanism.
- Ren, Yufeng,Yang, Bo,Liao, Xiali
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p. 22034 - 22042
(2016/03/08)
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- Synthesis of acridinedione derived mono spiro-pyrrolidine/pyrrolizidine derivatives - A facile approach via intermolecular [3+2] cycloaddition reaction
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A facile synthesis of acridinedione derived mono spiro-pyrrolidine and pyrrolizidine derivatives has been accomplished by 1,3-dipolar cycloaddition reaction. The O-acryloylacridinediones, as dipolarophiles reacted with azomethine ylide derived from di-/tr
- Rajesh,Suresh,Selvam,Raghunathan
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p. 4047 - 4053
(2014/07/22)
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- Aldonitrones as aldehyde equivalents: An efficient, green, and novel protocol for the synthesis of 1,8-dioxo-octahydroxanthenes
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A novel, self-catalyzed, solvent-free, microwave-enhanced, green, and efficient protocol for the synthesis of 1,8-dioxo-octahydroxanthenes and bis-5,5-dimethyl-1,3-cyclohexanediones by condensing aldo-nitrones (imine oxide) and dimedone (5,5-dimethyl-1,3-
- Kumar, Dhruva,Suresh,Sandhu, Jagir S.
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p. 2739 - 2747
(2013/08/23)
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- A bright entry to improve the performance of DSSCs with the influence of novel optoelectronic acridinedione based macromolecules in I-/I 3- electrolytes
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The performance of Ru(ii) dye-sensitized nanocrystalline TiO2 solar cells (DSSCs) is described with newly synthesized multivalent macromolecules, containing excellent optoelectronic acridinedione linked with 1,2,3-triazole units, via a novel and convenient Cu(I)-catalyzed alkyne and azide 1,3-dipolar cycloaddition (CuAAC) reaction. These unique macromolecules have proved to be highly suitable for utilizing additives in I -/I3- redox couple electrolytes. Among the various substitutions, the maximum photo-current conversion efficiency of about 6.4% with a Voc of 810 mV was obtained with electron rich substitutions in the nitrogen heteroatom.
- Periyasami, Govindasami,Rajesh, Raju,Arumugam, Natarajan,Raghunathan, Raghavachary,Ganesan, Shanmugam,Maruthamuthu, Picha
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p. 14666 - 14674
(2013/11/19)
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- An efficient and simple synthesis of tetraketones catalyzed by Yb(OTf) 3-sio2 under solvent free conditions
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A novel and efficient three-component one-pot condensation method has been described for the synthesis of tetraketones or arylmethylene[bis(3-hydroxy-2- cyclohexene-1-ones)] using Yb(OTf)3-SiO2 and amine as catalytic system under sol
- Kameshwara Rao,Kumar, Muthyala Manoj,Kumar, Anil
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experimental part
p. 1128 - 1135
(2011/10/04)
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- Specific ca2+ fluorescent sensor: Signaling by conformationally induced pet suppression in a bichromophoric acridinedione
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A series of acridinedione-based bichromophoric podand systems 1a-c were synthesized and characterized. Among these, bichromophore 1c shows specific binding of Ca2+ in the presence of other biologically important metal ions like Na+, K+, Mg2+, and Zn2+, The selective complexation was proved by steady-state emission, time-resolved emission, and 1H NMR titration. Signaling of the binding event was achieved by Ca2+-induced folding of the bichromophore, resulting in PET suppression in the acridinedione chromophore. Involvement of a PET process in the optical signaling was confirmed by comparing bichromophores 1a-c with non-PET compound 2 -and monochromophore model compound 3. Non-PET compound 2 failed to give optical response upon Ca2+ binding as a result of the absence of a POT process in the Ca2+-bound complex. Monochromophore 3 shows a similar optical response, which is the same as that in 1c. Titration of the metalion-bound complex of 1c with EDTA released the metal ion from the complex, thereby regaining the original photophysical properties of the bichromophore.
- Ashokkumar, Pichandi,Ramakrishnan, Vayalakkavoor T.,Ramamurthy, Perumal
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experimental part
p. 5941 - 5947
(2010/03/25)
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- Tetraketones: A new class of tyrosinase inhibitors
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Twenty-eight tetraketones (1-28) with variable substituents at C-7 were synthesized and evaluated as tyrosinase inhibitors. Remarkably compounds 25 (IC50 = 2.06 μM), 11 (IC50 = 2.09 μM), 15 (IC 50 = 2.61 μM), and 27 (ICsu
- Khan, Khalid Mohammed,Maharvi, Ghulam Murtaza,Khan, Mahmud Tareq Hassan,Jabbar Shaikh, Ahson,Perveen, Shahnaz,Begum, Saeedan,Choudhary, Mohammad Iqbal
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p. 344 - 351
(2007/10/03)
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- Synthesis of tetra- and octahydroxanthene derivatives by the condensation of dimedone with aromatic aldehydes
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The reaction of dimedone with salicyl and 2-hydroxy-1-naphthoyl aldehydes gave derivatives of tetrahydroxanthene and tetrahydrobenzo[a]xanthene and not aldimedone as occurs in condensations with other aldehydes. Derivatives of decahydroacridine were obtained by reaction of the tetrahydroxanthene derivatives with methyl-and ethylamine. Tetrahydro- and octahydroxanthene derivatives were obtained from the reaction of acetylsalicylaldehyde with dimedone in acetic anhydride. The structures of the ketoenol forms of the products containing a β-ketoenol unit were determined by 1H and 13C NMR spectroscopy, and the mechanism of their interconversion is discussed. 1997 Plenum Publishing Corporation.
- Pyrko
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p. 635 - 645
(2007/10/03)
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