Diarylamine Synthesis via Desulfinylative Smiles Rearrangement
Diarylamines are obtained directly from sulfinamides through a novel rearrangement sequence. The transformation is transition metal-free and proceeds under mild conditions, providing facile access to highly sterically hindered diarylamines that are otherw
Sephton, Thomas,Large, Jonathan M.,Butterworth, Sam,Greaney, Michael F.
p. 1132 - 1135
(2022/02/09)
Ligand-Enabled Gold-Catalyzed C(sp2)-N Cross-Coupling Reactions of Aryl Iodides with Amines
The first example of ancillary (P,N)-ligand-enabled gold-catalyzed C-N cross-coupling reactions of aryl iodides with amines is reported. The high generality of the reaction in de novo synthesis, late-stage modifications, and cascade processes to access functionalized indolinones and carbazoles underscores the synthetic potential of the presented strategy. Monitoring the reaction with ESI-HRMS and NMR provided strong evidence for the in situ formation of putative high valent Au(III) intermediates.
Akram, Manjur O.,Das, Avishek,Chakrabarty, Indradweep,Patil, Nitin T.