330561-87-0

Basic information

• Product Name: cyclopentanone [4-(4-bromophenyl)-1,3-thiazol-2-yl]hydrazone
• Synonyms: cyclopentanone [4-(4-bromophenyl)-1,3-thiazol-2-yl]hydrazone
• CAS NO: 330561-87-0
• Molecular Formula: C₁₄H₁₄BrN₃S
• Molecular Weight: 336.25006
• Mol File: 330561-87-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: cyclopentanone [4-(4-bromophenyl)-1,3-thiazol-2-yl]hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: cyclopentanone [4-(4-bromophenyl)-1,3-thiazol-2-yl]hydrazone(330561-87-0)
• EPA Substance Registry System: cyclopentanone [4-(4-bromophenyl)-1,3-thiazol-2-yl]hydrazone(330561-87-0)

Safety Data

• Hazardous Substances Data: 330561-87-0(Hazardous Substances Data)

Upstream product

• 7283-39-8 cyclopentanone thiosemicarbazone 
• 99-73-0 para-bromophenacyl bromide 

Relevant articles and documents

Application of alicyclic ketone hydrazone thiazole derivative serving as tyrosinase inhibitor

The invention discloses an alicyclic ketone hydrazone thiazole derivative having tyrosinase inhibiting activity. Screening results of in-vitro inhibition tyrosinase show that the synthesized derivative has the tyrosinase inhibiting activity. The compound

Synthesis of Biologically Active [4-(4-Bromophenyl)-2-thiazolyl]hydrazones and their D-Galactose Derivatives

Benzaldehyde [4-(4-bromophenyl)thiazol-2-yl]hydrazones 5a-5d were prepared by reacting the thiosemicarbazones 2a-2d with 2,4'-dibromoacetophenone (1) in absolute ethanol. Acetylation of 5a and 5b with Ac2O/Py at room temperature gave the N-acetyl derivatives 6a and 6b. 4-Methyl-2-pentanone/cyclopentanone [4-(4-bromophenyl) thiazol-2-yl]hydrazones (8a) and (8b) were similarly obtained from the reaction of 1 with the thiosemicarbazones 7a and 7b, respectively. Cyclization of D-galactose thiosemicarbazone (9) and its tautomers 10 and 11 with 1 afforded an equilibrium mixture of the acyclic 2-thiazolylhydrazone 12, together with its respective cyclic galactosyl derivatives 13 and 14, whose structures were studied by using 1H and 13C NMR spectra. The antimicrobial activity of the synthesized thiazole derivatives was evaluated in vitro by using an agar diffusion technique, and some of these compounds showed potential activity against Candida albicans.

Synthesis, anti-bacterial and anti-fungal activities of some novel Schiff bases containing 2,4-disubstituted thiazole ring

A series of arylidene-2-(4-(4-methoxy/bromophenyl) thiazol-2-yl) hydrazines (4a-z) and 1-(4-(4-methoxy/bromophenyl) thiazol-2-yl)-2-cyclohexylidene/cyclopentylidene hydrazines (5a-b/6a-b) were synthesized, characterized and screened for their antimicrobial activities. The structures of synthesized compounds were established by spectroscopic (FT-IR, 1H NMR, 13C NMR, Mass) and elemental analyses. Both the anti-bacterial and anti-fungal activities with MIC values of compounds were evaluated. The results of anti-bacterial screening reveal that among all the compounds screened eight compounds showed moderate to good anti-bacterial activity while ten of the newly synthesized compounds displayed good to excellent anti-fungal activity. Among the tested compounds, the most effective compounds with MIC value in the range of 6.25-25 μg/ml are 4a, 4n, 4z, 5a, 5b, 6a and 6b against three fungal strains viz. Candida albicans, Cryptococcus neoformans and Aspergillus flavus.

Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp.

In this paper, we report on the synthesis of a novel series of 2-thiazolylhydrazone derivatives and the influence of the substituents on the thiazole ring on antifungal activity. All synthesized compounds were screened for their in vitro activities agains