33095-94-2

Basic information

• Product Name: 1-(1,3-benzodioxol-5-yl)-1-isopropylurea
• Synonyms: 1-(1,3-benzodioxol-5-yl)-1-isopropylurea;1-(1,3-benzodioxol-5-yl)-1-propan-2-ylurea
• CAS NO: 33095-94-2
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.24046
• EINECS: 251-378-0
• Mol File: 33095-94-2.mol

Chemical Properties

• Boiling Point: 375.5°C at 760 mmHg
• Flash Point: 180.9°C
• Appearance: /
• Density: 1.286g/cm³
• Vapor Pressure: 7.75E-06mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: 1-(1,3-benzodioxol-5-yl)-1-isopropylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,3-benzodioxol-5-yl)-1-isopropylurea(33095-94-2)
• EPA Substance Registry System: 1-(1,3-benzodioxol-5-yl)-1-isopropylurea(33095-94-2)

Safety Data

• Hazardous Substances Data: 33095-94-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(1,3-benzodioxol-5-yl)-1-isopropylurea is used as a drug intermediate for its potential role in the development of treatments for neurological and psychiatric disorders. Its research is focused on its potential as a central nervous system stimulant, which could be beneficial for conditions such as ADHD, depression, and other related disorders.
Used in Agrochemical Industry:
1-(1,3-benzodioxol-5-yl)-1-isopropylurea is also used as a pesticide intermediate due to its diverse chemical properties. It plays a role in the synthesis of various agrochemicals, contributing to the development of new pesticides that can be more effective and environmentally friendly.
Further research and testing are needed to fully understand the potential applications and effects of 1-(1,3-benzodioxol-5-yl)-1-isopropylurea in both the pharmaceutical and agrochemical industries.

InChI:InChI=1/C11H14N2O3/c1-7(2)13(11(12)14)8-3-4-9-10(5-8)16-6-15-9/h3-5,7H,6H2,1-2H3,(H2,12,14)

Upstream product

• 917-61-3 sodium isocyanate 
• 10368-14-6 N-isopropyl-3,4-(methylenedioxy)aniline 
• 14268-66-7 benzo[1,3]dioxolo-5-ylamine 

Downstream Products

• 82448-22-4 8-(4-Benzyloxy-phenyl)-5-isopropyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinazolin-6-one 
• 85575-64-0 3-(5-Isopropyl-6-oxo-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]quinazolin-8-yl)-benzoic acid 
• 85575-63-9 5-Isopropyl-8-(3-trifluoromethyl-phenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinazolin-6-one 
• 33095-78-2 5-Isopropyl-8-p-tolyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinazolin-6-one 
• 33095-80-6 1-isopropyl-4-(p-fluorophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone 
• 33095-83-9 1-isopropyl-4-(m-nitrophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone 
• 33095-91-9 1-isopropyl-4-phenyl-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone 
• 82448-21-3 4-(5-Isopropyl-6-oxo-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]quinazolin-8-yl)-benzoic acid 
• 33095-84-0 1-isopropyl-4-(o-methylphenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone 
• 33095-77-1 1-isopropyl-4-(m-methoxyphenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone 
• 33095-81-7 1-isopropyl-4-(3,4-dichlorophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone 
• 33095-71-5 5-Isopropyl-8-(2-nitro-phenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinazolin-6-one 
• 33095-90-8 1-isopropyl-4-(m-fluorophenyl)-6,7-methylenedioxy-3,4-dihydro-2(1H)-quinazolinone 
• 82448-19-9 4-(5-Isopropyl-6-oxo-5,6-dihydro-[1,3]dioxolo[4,5-g]quinazolin-8-yl)-benzoic acid 

Relevant articles and documents

Substituted quinazolines and analogs and use thereof

The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus. Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.

Antiinflammatory Properties of 8-Aryl-5-isopropyl-2H-1,3-dioxoloquinazolin-6(5H)-ones and -thiones

A series of 8-aryl-5-isopropyl-2H-1,3-dioxoloquinazolin-6(5H)-ones and -thiones was prepared and evaluated for antiinflammatory activity.The 8-phenyl-, 8-(3-fluorophenyl)-, and 8-(4-fluorophenyl)-2H-1,3-dioxoloquinazolin-6(5H)-ones and the 8-phenyl-2H-1,3-dioxoloquinazolin-6(5H)-thione were found to exhibit activity in the range of indomethacin and proquazone.