33124-50-4

Basic information

• Product Name: fluocortin
• Synonyms: fluocortin;6α-Fluoro-11β-hydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-oic acid
• CAS NO: 33124-50-4
• Molecular Formula: C₂₂H₂₇FO₅
• Molecular Weight: 390.448
• EINECS: 251-383-8
• Mol File: 33124-50-4.mol

Chemical Properties

• Boiling Point: 543.2°Cat760mmHg
• Flash Point: 282.3°C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 4.57E-14mmHg at 25°C
• Refractive Index: 1.579
• CAS DataBase Reference: fluocortin(CAS DataBase Reference)
• NIST Chemistry Reference: fluocortin(33124-50-4)
• EPA Substance Registry System: fluocortin(33124-50-4)

Safety Data

• Hazardous Substances Data: 33124-50-4(Hazardous Substances Data)

Usage

Uses

Anti-inflammatory.

InChI:InChI=1/C22H27FO5/c1-10-6-13-12-8-15(23)14-7-11(24)4-5-21(14,2)18(12)16(25)9-22(13,3)17(10)19(26)20(27)28/h4-5,7,10,12-13,15-18,25H,6,8-9H2,1-3H3,(H,27,28)/t10-,12?,13+,15+,16+,17-,18?,21+,22+/m1/s1

Relevant articles and documents

Prodrug derivatives of carboxylic acid drugs

Novel ester derivatives of carboxylic acid medicaments of formula (I), wherein R--COO--represents the acyloxy residue of a carboxylic acid drug or medicament, n is an integrer from 1 to 3, and R1 and R2 are the same or different and are selected from a group consisting of an alkyl, an alkenyl, an aryl, an aralkyl, a cycloalkyl and which group may be unsubstituted or substituted, or R1 and R2 together with the N forms a 4-, 5-, 6- or 7-membered heterocyclic ring, which in addition to the nitrogen atom may contain one or two further heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur and which heterocyclic group may be substituted. These compounds are highly biolabile prodrug forms of the corresponding carboxylic acid compounds and are highly susceptible to undergoing enzymatic hydrolysis in vivo whereas they are highly stable in aqueous solution. The novel derivatives are less irritating to mucosa than the parent carboxylic acids and may provide an improved bio-availability of the drugs.

Novel pregnanoic acid derivatives

Steroids of the formula SPC1 Wherein X is a hydrogen atom, a halogen atom or methyl; Y is a hydrogen atom or a halogen atom; Z is carbonyl, β-acyloxymethylene or, when Y is a hydrogen atom, also methylene; R1 is a hydrogen atom or methyl; R2 is a hydrogen atom, an alkali metal atom or optionally substituted hydrocarbon; and --A--B-- is --CH=CH--, --CCl=CH-- or when at least one of X, Y and R1 is other than a hydrogen atom, --CH2 --CH2 --, which can be produced by oxidizing a corresponding 20-hydroxy steroid or a corresponding 21-aldehyde, possess topical anti-inflammatory activity.