331751-81-6

Basic information

• Product Name: 8-((4-chlorobenzyl)thio)-3-methyl-7-propyl-3,7-dihydro-1H-purine-2,6-dione
• Synonyms: 8-((4-chlorobenzyl)thio)-3-methyl-7-propyl-3,7-dihydro-1H-purine-2,6-dione;8-[(4-chlorobenzyl)sulfanyl]-3-methyl-7-propyl-3,7-dihydro-1H-purine-2,6-dione
• CAS NO: 331751-81-6
• Molecular Formula: C16H17ClN4O2S
• Molecular Weight: 364.84978
• Mol File: 331751-81-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-((4-chlorobenzyl)thio)-3-methyl-7-propyl-3,7-dihydro-1H-purine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 8-((4-chlorobenzyl)thio)-3-methyl-7-propyl-3,7-dihydro-1H-purine-2,6-dione(331751-81-6)
• EPA Substance Registry System: 8-((4-chlorobenzyl)thio)-3-methyl-7-propyl-3,7-dihydro-1H-purine-2,6-dione(331751-81-6)

Safety Data

• Hazardous Substances Data: 331751-81-6(Hazardous Substances Data)

Upstream product

• 2434-53-9 6-amino-1-methyluracil 
• 622-95-7 4-chlorobenzyl bromide 
• 14094-37-2 6-amino-5-bromo-1-methylpyrimidine-2,4(1H,3H)-dione 
• 125092-42-4 6-amino-1-methyl-5-(propylamino)pyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

Ligand-based design, synthesis and biological evaluation of xanthine derivatives as LSD1/KDM1A inhibitors

Histone lysine specific demethylase 1 (LSD1) has been recognized as an important epigenetic target for disease treatment. To date, a large number of LSD1 inhibitors have been developed, some of which are currently being evaluated in clinical trials for th

Xanthine LSD1 inhibitor and preparation method and application thereof

The invention belongs to the field of medicinal chemistry, and discloses a xanthine structure containing LSD1 inhibitor, a synthesizing method and related application. The xanthine LSD1 inhibitor is characterized in that the structure formula is shown in the description, wherein R1 is benzyl; R2 is 1-3 alkyl and carboxylic acid derivates; R3 is heteroatom substituted hexatomic ring. The LSD1 enzymatic activity detection result shows that the xanthine compound of such series is good in effect on inhibiting LSD1 and can be used as a lead compound, and on that basis, a novel LSD inhibitor is further designed (refer to Specification).