- Synthesis method of alinidine medical intermediate 2-(N-allyl-N-2,6-dichlorophenyl)amino-imidazoline
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A synthesis method of an alinidine medical intermediate 2-(N-allyl-N-2,6-dichlorophenyl)amino-imidazoline includes the following steps of adding 0.13 mol of 2-(N-2,6-dichlorophenyl)amino-imidazoline, 110 ml of nitromethane and 0.11 mol of sodium sulfite to a reaction vessel provided with a stirrer, a reflux condenser and a dropping funnel, controlling the stirring speed at 130-160 rpm, slowly adding 0.16-0.19 mol of allyl amine, raising the temperature of the solution to 60-65 DEG C after addition, conducting refluxing for 5-6 h, lowing the temperature of the solution to 10-15 DEG C, conducting filtering, reducing pressure to steam out nitromethane, adding 210 ml of oxalic acid to remaining oily matter, conducting decoloration through a molecular sieve, conducting filtering, regulating the pH of filtrate through a potassium bisulfite regulation solution to 9-10, separating out solid, conducting suction filtration, saline solution washing and cyclohexane washing, conducting dehydration through a dehydrating agent, and conducting recrystallization in propionitrile to obtain crystal 2-(N-allyl-N-2,6-dichlorophenyl)amino-imidazoline.
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Paragraph 0014; 0015
(2016/11/28)
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- Chemistry, Pharmacology, and Structure-Activity Relationships with a New Type of Imidazolines Exerting a Specific Bradycardic Action at a Cardiac Site
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The reaction of alkyl halides with 2-(arylimino)imidazolidines (I) leads to imidazoline derivatives II, in which the side chain is situated at the bridge nitrogen atom between the phenyl group and the imidazoline ring.The new imidazolines (II) exert a spe
- Staehle, Helmut,Daniel, Helmut,Kobinger, Walter,Lillie, Christian,Pichler, Ludwig
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p. 1217 - 1222
(2007/10/02)
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