- Synthesis and Reactivity of some 1,2,4-Triazolopyridazine Derivatives
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The triazolopyridazine derivatives were obtained in the reaction of 3-chloro-6-hydrazinopyridazine with acetic acid and ethyl chloroformate.Acting on 6-chloro-3-methyl-1,2,4-triazolopyridazine with phosphorus pentachloride, a methyl group in position 3 has unexpectedly been exchanged by chlorine.The mechanism of fusing the triazole ring to the pyridazine system has been studied by the reaction of 3-chloro-6-hydrazinopyridazine with formaldehyde, acetaldehyde, and treatment the resulting Schiff bases by bromine in acetic acid with sodium acetate added.Key words: 1,2,4-Triazolopyridazines, nucleophilic substitution, cyclization mechanism
- Baloniak, S.,Katrusiak, A.
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p. 683 - 692
(2007/10/02)
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