Cobalt-catalyzed electrochemical cross-coupling of functionalized phenyl halides with 4-chloroquinoline derivatives
A novel electrochemical procedure allowing the synthesis of various 4-phenylquinoline derivatives in satisfactory to high yields is described. This method relies on a cobalt-catalyzed cross-coupling reaction of functionalized phenyl halides with 4-chloroquinoline derivatives and is conducted in a one-compartment cell using the sacrificial anode process.
Le Gall, Erwan,Gosmini, Corinne,Nédélec, Jean-Yves,Périchon, Jacques
Efficient cobalt-catalyzed formation of unsymmetrical biaryl compounds and its application in the synthesis of a sartan intermediate
(Chemical Equation Presented) No prior preparation of the organometallic reagent is required in a cobalt-catalyzed coupling of two different aryl halides under mild conditions (see scheme). A broad spectrum of valuable biaryl compounds can be prepared in this way. Not only may a variety of reactive substituents be present, but heteroaryl halides and aryl triflates are also suitable substrates. DMF = N,N-dimethylformamide, FG = functional group.
Amatore, Muriel,Gosmini, Corinne
supporting information; experimental part
p. 2089 - 2092
(2009/02/06)
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