- Synthesis of a phenylboronic acid-functionalized thermosensitive block copolymer and its application in separation and purification of vicinal-diol-containing compounds
-
A phenylboronic acid-functionalized amphiphilic thermosensitive block copolymer was prepared by taking PEO20PPO60PEO20 as the template and a detailed study of its performance in downstream separation processes was presented. Alizarin red was used as the model compound to study the feasibility of using an affinity adsorption system and aqueous two-phase flotation system based on the phenylboronic acid-functionalized PEO20PPO60PEO20 for the separation and purification of ortho-hydroxyl compounds. The optimized conditions of the affinity adsorption experiment were: 2% phenylboronic acid-functionalized PEO20PPO60PEO20, 0.3 mg alizarin red, 40% K2HPO4 and 4 h adsorption time. The affinity adsorption rate of alizarin red reached 98% under such conditions. In addition, a flotation recovery of alizarin red of 97% was obtained under the optimal conditions of aqueous two-phase flotation: 0.3 g of collector, 12 g K2HPO4, 0.6 mg alizarin red, 15 mL min-1 nitrogen flow rate and 40 min flotation time. Both methods are capable of separating alizarin red, suggesting their broad application prospect in downstream separation engineering of vicinal-diol-containing compounds.
- Wang, Yun,Li, Yuanyuan,Han, Juan,Tang, Xu,Ni, Liang,Hu, Xiaowei,Wang, Lei
-
-
Read Online
- NANOPARTICLES STABILIZED WITH NITROPHENYLBORONIC ACID COMPOSITIONS
-
PROBLEM TO BE SOLVED: To provide nanoparticles comprising a polyol-containing polymer and a nitrophenylboronic acid-containing polymer, for effective and specific delivery of a compound of interest. SOLUTION: A nanoparticle comprises a polyol-containing polymer coupled through a reversible covalent linkage to a nitrophenylboronic acid-containing polymer. The nitrophenylboronic acid-containing polymer is configured to be present in an environment external to the nanoparticle. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
- -
-
Paragraph 0274; 0276
(2019/08/16)
-
- TARGETED NANOPARTICLES
-
PROBLEM TO BE SOLVED: To provide nanoparticles for effective and specific delivery of drugs. SOLUTION: A carrier nanoparticle comprises a polyol-containing polymer coupled through a reversible covalent linkage to a boronic acid-containing polymer, particularly a polymer containing a nitrophenylboronic acid group. The nanoparticle is configured to present the boronic acid-containing polymer to an external environment. The boronic acid-containing polymer is conjugated to a targeting ligand at its terminal end opposite the nanoparticle. SELECTED DRAWING: Figure 16 COPYRIGHT: (C)2019,JPOandINPIT
- -
-
Paragraph 0274-0276
(2019/08/16)
-
- Nitro phenyl boron acid composition stabilized nanoparticles (by machine translation)
-
[Problem] to provide for delivery of the compounds of the nano-particle carrier. [Solution] boronic acid-containing polymer polyol containing polymer nanoparticles with a coupling. The nanoparticles, the nanoparticles present in the environment outside of the boronic acid containing polymers as nanoparticles. Targeting nanoparticles version and related compositions, method and system. Figure 1 [drawing] (by machine translation)
- -
-
Paragraph 0276; 0277
(2018/05/24)
-
- NANOPARTICLES STABILIZED WITH NITROPHENYLBORONIC ACID COMPOSITIONS
-
Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.
- -
-
Paragraph 0303
(2014/09/16)
-
- TARGETED NANOPARTICLES
-
Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.
- -
-
Paragraph 242
(2014/09/16)
-
- TARGETED NANOPARTICLES
-
Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external to the nanoparticle. Targeted versions of the described nanoparticles are also described, as are related compositions, methods and systems.
- -
-
Paragraph 0387
(2014/09/16)
-
