332177-01-2Relevant articles and documents
Synthesis, characterization, biological evaluation and docking of some novel substituted 1, 3-thiazine derivatives
Bairam, Ravindar,Muppavarapu, Srinivasa Murthy,Sreekanth, Sivan
, p. 233 - 242 (2017/04/04)
Objective: Chalcones and their heterocyclic analogs represent an important class of small molecules which have a wide range of pharmacological activities. Therefore, in this study, synthesis and anticonvulsant and antimicrobial activities of some new 1, 3
Synthesis, characterization, and crystal structures of α, α'-bis(substituted-benzylidene)cycloalkanone derivatives by nano-TiO2/HOAc
Tabrizian, Elham,Amoozadeh, Ali,Rahmani, Salman,Salehi, Mehdi,Kubicki, Maciej
, p. 531 - 544 (2016/04/26)
A new and economical synthesis of α, α'-bis(substituted-benzylidene)cycloalkanones has been achieved by the reaction of cycloalkanones with different aromatic aldehydes using nano-TiO2/acetic acid as a catalyst in ethanol under reflux conditions with excellent yields. Five new products and three new single crystal structures are reported.
Nano titania-supported sulfonic acid catalyzed synthesis of α,α'-bis(substituted-benzylidene)cycloalkanones and of their xanthene derivatives under solvent-free conditions
Amoozadeh, Ali,Tabrizian, Elham,Rahmani, Salman
, p. 848 - 857 (2015/08/06)
An efficient, rapid and green synthesis of α,α'-bis(substituted-benzylidene)cycloalkanones and their xanthene derivatives is reported under solvent-free conditions using nano titania-supported sulfonic acid (n-TSA) as a reusable catalyst. This method offers many advantages, such as environmental friendliness reaction conditions, simplicity, short reaction times, easy work-up, reusability of catalyst, and high yields of products. Eight new compounds are reported too.
Organocatalytic enantioselective desymmetrization of cyclic enones via phosphine promoted [3+2] annulations
Pinto, Nathalie,Retailleau, Pascal,Voituriez, Arnaud,Marinetti, Angela
supporting information; experimental part, p. 1015 - 1017 (2011/02/28)
Phosphine catalyzed enantioselective [3+2] cyclizations on 4-substituted 2,6-diarylidenecyclohexanones and 2,4-diarylidene-bicyclo[3.1.0]hexan-3-ones take place with high diastereo- and enantioselectivity levels. The process affords spirocyclic compounds with excellent stereochemical control of up to five stereogenic centres.
Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones
Dimmock, Jonathan R.,Padmanilayam, Maniyan P.,Zello, Gordon A.,Nienaber, Kurt H.,Allen, Theresa M.,Santos, Cheryl L.,De Clercq, Erik,Balzarini, Jan,Manavathu, Elias K.,Stables, James P.
, p. 169 - 177 (2007/10/03)
A series of 2,6-bis(arylidene)cycloalkanones (1) and related compounds containing one or two substituents at the four position of the cyclohexyl ring were prepared and shown to display cytotoxic activity towards murine P388 and L1210 cells as well as human Molt 4/C8 and CEM T-lymphocytes. In some of the series of compounds, positive correlations were noted between the potencies of the enones and the magnitude of the Hammett σ values of the aryl substituents. Four representative compounds were cytotoxic to a number of human tumours in vitro, particularly towards colon cancer and leukemic cells. A noteworthy feature of the compounds prepared in this study is that, in general, they were well tolerated when administered to rodents. A number of lead molecules emerged from this investigation as well as guidelines for future expansion of these series of compounds.
