Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents
A series of fused and functionalized pyridine derivatives were designed, synthesized and tested for their potential antitubercular properties. All these novel compounds were prepared by using multistep methods involving the construction of pyridine ring as a key synthetic step. Some of these compounds were found to be interesting when tested for their antitubercular properties in vitro and one of them appeared as an attractive and potential antitubercular agent.
Dulla, Balakrishna,Wan, Baojie,Franzblau, Scott G.,Kapavarapu, Ravikumar,Reiser, Oliver,Iqbal, Javed,Pal, Manojit
supporting information; experimental part
p. 4629 - 4635
(2012/07/31)
Synthesis of substituted 1,2,3,4-tetrahydroquinoline-4-carboxylic acids
Reduction of some substituted quinoline-4-carboxylic acids was studied. The reduction of 2-alkylquinoline-4-carboxylic acids with Raney nickel in aqueous alkali was stereoselective, and the resulting 2-alkyl-1,2,3,4- tetrahydroquinoline-4-carboxylic acids
Zhuravleva,Zimichev,Zemtsova,Klimochkin
experimental part
p. 609 - 612
(2009/09/06)
Use of imidazo?1,5-a!quinolones as neuroprotective agents
The imidazo?1,5-a!quinolines (I) are useful in treating neurological diseases/conditions or chronic neurodegenerative diseases/conditions.
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(2008/06/13)
Imidazo[1,5-A]quinolines for treatment of anxiety and sleep disorders
Imidazo[1,5-a]quinolines of formula (I) which are useful pharmaceutical agents for the treatment of anxiety, sleep disorders, panic states, convulsions and muscle disorders. STR1
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(2008/06/13)
Certain 2-oxo-quinoline carboxylates or corresponding carboxamides useful as anti-emetics and suppressants of migraine
There is disclosed a heterocyclic compound represented by general formula: STR1 wherein R1 represents hydrogen, lower alkyl or aryl; R2 represents hydrogen, hydroxyl or lower alkyl; A represents CH or N; X represents --O-- or --NH--; R3 represents hydrogen, hydroxyl or lower alkyl; R4 represents lower alkyl; represents 0 or 1, or a pharmaceutically acceptable salt thereof.
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(2008/06/13)
5-HT3 Receptor Antagonists. 1. New Quinoline Derivatives
A series of esters and amides of 1-alkyl-2-oxo-1,2-dihydroquinoline-4-carboxylic acid or 2-alkoxyquinoline-4-carboxylic acid containing a basic azabicycloalkyl moiety has been synthesized and evaluated for affinity for the 3H>quipazine-labeled