33329-27-0

Basic information

• Product Name: 2-(2-methyl-4-nitrophenyl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-(2-methyl-4-nitrophenyl)-1H-isoindole-1,3(2H)-dione
• CAS NO: 33329-27-0
• Molecular Weight: 282.255
• Mol File: 33329-27-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(2-methyl-4-nitrophenyl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methyl-4-nitrophenyl)-1H-isoindole-1,3(2H)-dione(33329-27-0)
• EPA Substance Registry System: 2-(2-methyl-4-nitrophenyl)-1H-isoindole-1,3(2H)-dione(33329-27-0)

Safety Data

• Hazardous Substances Data: 33329-27-0(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 99-52-5 2-methyl-4-nitro-benzenamine 

Downstream Products

• 33329-28-1 2-(4-amino-2-methylphenyl)isoindoline-1,3-dione 

Relevant articles and documents

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Synthesis and?biological activity of?6H-isoindolo[2,1-a]indol-6-ones, analogues of?batracylin, and?related compounds

Closely related to batracylin, 6H-isoindolo[2,1-a]indol-6-ones including 2-nitro- 13a, 2-amino- 14, and 2-diethylaminopropionamide derivative 16 as well as D-ring substituted 13b, 13c or A-ring substituted 13d and 20 analogues, were synthesised and evaluated against L1210 leukaemia. Subsequent treatment of 13b and 13c with N,N-diethylethylenediamine at 180?°C, led to compounds 17a and 17b arising from an unexpected opening of the pyrrolidinone ring and amidification of the keto group. Under the same conditions, the dichloro derivative 13d led to the monoalkyl compound 20 which was the most cytotoxic of the series.

Synthesis and anticonvulsant and neurotoxic properties of substituted N- phenyl derivatives of the phthalimide pharmacophore

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