Chiral oxazaborolidinone-mediated enantioselective ring-cleavage reaction of a mixture of diastereomeric 1,3-dioxolane acetals: Application to asymmetric desymmetrization of meso-1,2-diols
Ring-cleavage reaction of a mixture of diastereomeric dioxolane acetals syn- and anti-1b-e proceeds in an enantiodifferentiating manner in the presence of chiral Lewis acid 2. The reaction is utilized as a key step in asymmetric desymmetrization of meso-1,2-diols.