334476-64-1

Basic information

• Product Name: VESTIPITANT MESYLATE
• Synonyms: VESTIPITANT MESYLATE;GW 597588B;GW 597599;GW 597599B;BHECXGHXWKHZOY-DXPOFMJKSA-N
• CAS NO: 334476-64-1
• Molecular Formula: C24H28F7N3O4S
• Molecular Weight: 587.5506424
• Mol File: 334476-64-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: VESTIPITANT MESYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: VESTIPITANT MESYLATE(334476-64-1)
• EPA Substance Registry System: VESTIPITANT MESYLATE(334476-64-1)

Safety Data

• Hazardous Substances Data: 334476-64-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Vestipitant mesylate is used as an Antidepressant/anti-anxiety agent for the treatment of mood disorders such as depression and anxiety. It works by blocking the NMDA receptors, which are involved in the regulation of mood and emotional responses.
Used in Gastroenterology:
Vestipitant mesylate is used as an antiemetic agent for the prevention of nausea and vomiting, which can be caused by various factors such as chemotherapy, pregnancy, or motion sickness.
Used in Gastroenterology (continued):
Vestipitant mesylate is also used in the treatment of functional dyspepsia, a chronic disorder characterized by persistent or recurrent upper abdominal pain or discomfort without any identifiable organic cause.
Used in Gastroenterology (continued):
Additionally, it is used for the treatment of irritable bowel syndrome (IBS), a common gastrointestinal disorder that affects the large intestine and causes symptoms such as abdominal pain, bloating, and changes in bowel habits.
Used in Gastroenterology (continued):
Vestipitant mesylate is also utilized in the management of gastroesophageal reflux disease (GERD), a condition where stomach acid frequently flows back into the esophagus, causing irritation and discomfort.

Upstream product

• 75-75-2 methanesulfonic acid 
• 1192874-46-6 1,1-dimethylethyl (3S)-4-{[{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}(methyl)amino]carbonyl}-3-(4-fluoro-2-methylphenyl)-1-piperazinecarboxylate 

Relevant articles and documents

Synthesis of the NK1 receptor antagonist GW597599. Part 3: Development of a scalable route to a key chirally pure arylpiperazine urea, a happy end

GW597599 1 is a novel NK-1 antagonist currently under investigation for the treatment of central nervous system disorders and emesis. The initial chemical development synthetic route, derived from the one used by medicinal chemistry, involved several haza

Chemical compounds

The invention relates to piperazine derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to their medical use. The novel compounds are antagonists of tachykinins, including substance P and other neurokinins.