Synthesis of Chiral Piperazines via Hydrogenation of Pyrazines Activated by Alkyl Halides
A facile method has been developed for the synthesis of chiral piperazines through Ir-catalyzed hydrogenation of pyrazines activated by alkyl halides, giving a wide range of chiral piperazines including 3-substituted as well as 2,3- and 3,5-disubstituted
Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis- trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor
In an effort to discover novel druglike NK1 receptor antagonists a new series of suitably substituted C-phenylpiperazine derivatives was identified by an appropriate chemical exploration of related N-phenylpiperazine analogues, with the specifi
Di Fabio, Romano,Griffante, Cristiana,Alvaro, Giuseppe,Pentassuglia, Giorgio,Pizzi, Domenica A.,Donati, Daniele,Rossi, Tino,Guercio, Giuseppe,Mattioli, Mario,Cimarosti, Zadeo,Marchioro, Carla,Provera, Stefano,Zonzini, Laura,Montanari, Dino,Melotto, Sergio,Gerrard, Philip A.,Trist, David G.,Ratti, Emiliangelo,Corsi, Mauro
experimental part
p. 3238 - 3247
(2010/04/03)
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