334997-03-4Relevant articles and documents
Compositions comprising oxophosphonate-based metalloproteinase inhibitors
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Page/Page column 19, (2008/06/13)
The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha
Carbamoylphosphonate MMP inhibitors. Part 4: The influence of chirality and geometrical isomerism on the potency and selectivity of inhibition
Breuer, Eli,Katz, Yiffat,Hadar, Rivka,Reich, Reuven
, p. 2415 - 2420 (2007/10/03)
Matrix metalloproteinases (MMPs) are a family of over twenty zinc-dependent enzymes that hydrolyze connective tissue and are involved in a variety of diseases, which are associated with undesired tissue breakdown. Previously we described the synthesis of
Carbamoylphosphonates, a new class of in vivo active matrix metalloproteinase inhibitors. 1. Alkyl- and cycloalkylcarbamoylphosphonic acids
Breuer, Eli,Salomon, Claudio J.,Katz, Yiffat,Chen, Weibin,Lu, Shuiming,R?schenthaler, Gerd-Volker,Hadar, Rivka,Reich, Reuven
, p. 2826 - 2832 (2007/10/03)
Matrix metalloproteinases (MMPs) are a family of over 20 zinc-dependent enzymes that hydrolyze connective tissue and are involved in a variety of diseases, which are associated with undesired tissue breakdown. This paper reports the synthesis, characteriz