33512-03-7

Basic information

• Product Name: 2,2-Oxiranedicarbonitrile, 3-(4-chlorophenyl)-
• CAS NO: 33512-03-7
• Molecular Formula: C10H5ClN2O
• Molecular Weight: 204.615
• Mol File: 33512-03-7.mol

Chemical Properties

• CAS DataBase Reference: 2,2-Oxiranedicarbonitrile, 3-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Oxiranedicarbonitrile, 3-(4-chlorophenyl)-(33512-03-7)
• EPA Substance Registry System: 2,2-Oxiranedicarbonitrile, 3-(4-chlorophenyl)-(33512-03-7)

Safety Data

• Hazardous Substances Data: 33512-03-7(Hazardous Substances Data)

Upstream product

• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 104-88-1 4-chlorobenzaldehyde 
• 109-77-3 malononitrile 

Downstream Products

• 66702-61-2 2-(4-chloro-phenyl)-3-oxo-2,3-dihydro-thiazolo[3,2-a]pyrimidinylium betaine 
• 41226-82-8 2-(4-chloro-phenyl)-3-(4-methoxy-phenyl)-4-(4-nitro-phenyl)-oxazolidine-5,5-dicarbonitrile 
• 56526-36-4 5-(4-chloro-phenyl)-thiazol-4-one 
• 66702-55-4 5-(4-chloro-phenyl)-3-ethyl-4-oxo-2-phenyl-4,5-dihydro-thiazolium betaine 
• 66702-45-2 3-benzyl-5-(4-chloro-phenyl)-4-oxo-2-phenyl-thiazolidine-2-carbonitrile 
• 59208-08-1 3-benzyl-5-(4-chloro-phenyl)-4-oxo-2-phenyl-4,5-dihydro-thiazolium betaine 
• 66702-59-8 5-(4-chloro-phenyl)-2-cyano-4-oxo-3-phenyl-4,5-dihydro-thiazolium betaine 
• 66702-53-2 5-(4-chloro-phenyl)-2-(4-nitro-phenyl)-4-oxo-3-phenyl-4,5-dihydro-thiazolium betaine 
• 66702-46-3 5-(4-chloro-phenyl)-2-methyl-4-oxo-3-phenyl-thiazolidine-2-carbonitrile 
• 59208-10-5 5-(4-chloro-phenyl)-2-methyl-4-oxo-3-phenyl-4,5-dihydro-thiazolium betaine 
• 41226-83-9 2-(4-chloro-phenyl)-3,4-bis-(4-methoxy-phenyl)-oxazolidine-5,5-dicarbonitrile 
• 41226-85-1 2-(4-chloro-phenyl)-4-(4-methoxy-phenyl)-3-(4-nitro-phenyl)-oxazolidine-5,5-dicarbonitrile 
• 59484-45-6 5-(4-chloro-phenyl)-2-methyl-thiazol-4-one 
• 51856-32-7 2-amino-5-(4-chloro-phenyl)-thiazol-4-one 

Relevant articles and documents

Pyrenediones as versatile photocatalysts for oxygenation reactions with: In situ generation of hydrogen peroxide under visible light

Pyrenediones (PYDs) are efficient photocatalysts for three oxygenation reactions: Epoxidation of electron deficient olefins, oxidative hydroxylation of organoborons, and oxidation of sulfides via in situ generation of H2O2 under visible light irradiation, using oxygen as a terminal oxidant and IPA as a solvent and a hydrogen donor.

Access to thiomorpholin-3-one derivatives: [3 + 3]-cycloadditions of α-chlorohydroxamates and 1,4-dithiane-2,5-diol

A protocol of [3 + 3]-cycloaddition was proposed for the synthesis of 2H-1,4-thiazin-3(4H)-ones and thiomorpholine-3,5-diones from α-chlorohydroxamates and 1,4-dithiane-2,5-diol. This direct and practical method provides a novel and rapid approach for the

Hypervalent Iodine(III)-Catalyzed Epoxidation of β-Cyanostyrenes

A convenient approach for the synthesis of β-cyanoepoxides is illustrated by iodine(III)-catalyzed epoxidation of electron-deficient β-cyanostyrenes, wherein the active catalytic iodine(III) species was generated in situ. The epoxidation of β-cyanostyrenes was performed using 10 molpercent PhI as precatalyst in the presence of 2.0 equivalents Oxone as an oxidant and 2.4 equivalents of TFA as an additive at room temperature under ultrasonic radiations. The β-cyanoepoxides were isolated in good to excellent yields in a short reaction time.

Ultrasound-assisted rapid synthesis of β-cyanoepoxides using hypervalent iodine reagents

An elegant approach for the rapid synthesis of β-cyanoepoxides 3 by the epoxidation of β-cyanostyrenes 1 with PIDA 2a is described. The epoxidation of β-cyanostyrenes 1 was performed with 1.2 equiv. of PIDA 2a in MeCN-H2O (1:1) at room temperature in ultrasonic bath. The epoxidation reactions were completed in short reaction time and β-cyanoepoxides 3 were isolated in 69–94% yields.

Epoxidation of vinyl cyanides by calcium hypochlorite under catalyst- and solvent-free conditions

In this paper, epoxidation of a wide range of alkenes by calcium hypochlorite (Ca(OCl)2) was investigated under catalyst- and solvent-free conditions. It was noticed that the highest yield was achieved with crushing, when the reaction was betwe

Chemoenzymatic Synthesis of α-Cyano Epoxides by a Tandem-Knoevenagel-Epoxidation Reaction

An efficient lipase-mediated synthesis of α-cyano epoxides through a tandem-Knoevenagel-epoxidation reaction was explored for the first time. This method provides a green, mild, and convenient route for the synthesis of α-cyano epoxides; moreover, the app

Asymmetric Epoxidation of Alkylidenemalononitriles: Key Step for One-Pot Approach to Enantioenriched 3-Substituted Piperazin-2-ones

The first enantioselective epoxidation of readily available alkylidenemalononitriles has been developed by using a multifunctional cinchona derived thiourea as the organocatalyst and cumyl hydroperoxide as the oxidant. A new simple one-pot asymmetric epox

Synthesis, characterization and mass spectrometric fragmentation of gem-dicyanooxiranes derived from benzylidene malononitrile

Benzylidene Malononitriles react with calcium hypochlorite in carbon tetrachloride at room temperature to afford substituted phenyl-1,1′-dicyanooxiranes, a class of important synthetic intermediates. The structure of these phenyl gem-dicyanooxiranes have

Facile Epoxidation of Alumina-Supported Electrophilic Alkenes and Montmorillonite-Supported Electrophilic Alkenes with Sodium Hypochlorite

Alkenes gem-substituted by two electron-withdrawing substituents, dispersed on alumina or montmorillonite, are conveniently epoxided by sodium hypochlorite.A mixture of aldehyde and methylcyanoacetate or malononitrile, treated with alumina and sodium hypo

SYNTHESES D'ESTERS OU D'ACIDES α-HALOGENES A PARTIR DES GEM DICYANO EPOXIDES.

α-halogeno esters or α-halogenoacids were easily prepared by selective one pot reaction of gem-dicyano epoxides with halohydric acids in an alcoholic or aqueous media.