cas 335165-68-9, 3,6-DIBROMO-ALPHA-(1-PIPERAZINYLMETHYL)-9H-CARBAZOLE-9-ETHANOL DIHYDROCHLORIDE | Articles data ｜lookchem

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335165-68-9

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3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome C release via bax channel modulation
There is compelling evidence that Bax channel activity stimulates cytochrome c release leading ultimate]y to cell death, which is a key event in ischemic injuries and neurodegenerative diseases. Here 3,6-dibromocarbazole piperazine derivatives of 2-propan
Bombrun, Agnes,Gerber, Patrick,Casi, Giulio,Terradillos, Olivier,Antonsson, Bruno,Halazy, Serge
p. 4365 - 4368
(2007/10/03)

9-(Piperazinylalkyl)carbazoles as Bax-modulators
The present invention is related to piperazine derivatives of carbazole notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such piperazine derivatives of carbazole. Said piperazine derivatives of car
-
(2008/06/13)

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Chemical Properties

Boiling Point: 388.1°C at 760 mmHg
Flash Point:188.5°C
Solubility:≥28.2 mg/mL in DMSO with ultrasonic; insoluble in EtOH; insoluble in H2O
Storage Temp.:Desiccate at RT
Vapor Pressure: 1.02E-06mmHg at 25°C
PSA: 40.43000
LogP: 5.45630

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