- A continuous water removal product and production method
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The invention relates to a method for continuous water removal production of amide product; first, ammonium salt is produced by pre neutralization reaction of raw material carboxylic acid and amine, the ammonium salt is further dehydrated to obtain amide and by-product water. According to the method, by countercurrent contact recycle gas and raw material amine desorption, carrying, condensation separation, the by-product water is timely moved out of the reaction section, the reaction is promoted, the amine circulation proportion is reduced, and the material loss is reduced. The amide product prepared by the method not only can be used in natural organic carboxylic acids, and is also applicable to synthesized aromatic carboxylic acids, the process is clean and environmentally-friendly; and the product amide is high in purity and free of salt.
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Paragraph 0024; 0025; 0026; 0027
(2017/04/08)
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- A novel aromatic carbocation-based coupling reagent for esterification and amidation reactions
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A novel tropylium-based coupling reagent has been developed to facilitate the synthesis of a series of esters, amides, lactones and peptides under mild reaction conditions. Remarkably, this reagent can be used in catalytic amounts in conjunction with a sacrificial reagent, offering a new and efficient method for nucleophilic coupling reactions of carboxylic acids.
- Nguyen, Thanh V.,Lyons, Demelza J.M.
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supporting information
p. 3131 - 3134
(2015/06/17)
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- An easy access to tertiary amides from aldehydes and N,N- dialkylchlorothiophosphoramidates
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A mechanistically unprecedented approach for the formation of tertiary amides from N,N-dialkylchlorothiophosphoramidates and aldehydes has been developed. The reaction occurred via the activation of aldehydes with N,N-dialkylchlorothiophosphoramidates followed by amidation with dialkylamine pendent of the same phosphoramidate.
- Pathak, Uma,Bhattacharyya, Shubhankar,Pandey, Lokesh Kumar,Mathur, Sweta,Jain, Rajeev
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p. 3900 - 3903
(2014/01/06)
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- Dodecanoic acid derivatives: Synthesis, antimicrobial evaluation and development of one-target and multi-target QSAR models
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In this study a series of dodecanoic acid derivatives (1-30) were synthesized and evaluated for in vitro antimicrobial activity against the panel of Gram positive, Gram negative bacterial and fungal strains. 4-Nitro phenyl dodecanoate (4) and quinolin-8-yl dodecanoate (5) emerged as most effective antibacterial agents, and 1-(4-benzylpiperazin- 1-yl) dodecan-1-one (15) was found to be the most effective antifungal agent amongst the synthesized dodecanoic acid derivatives. Quantitative structure activity relationship (QSAR) studies performed by the development of one-target and multi-target models indicated that multitarget model was effective in describing the antimicrobial activity of dodecanoic acid derivatives as well demonstrated the importance of topological parameter, zero-order molecular connectivity index (0X). Springer Science+Business Media, LLC 2010.
- Sarova, Devinder,Kapoor, Archana,Narang, Rakesh,Judge, Vikramjeet,Narasimhan, Balasubramanian
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experimental part
p. 769 - 781
(2012/05/20)
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- A convenient method for the synthesis and one-pot reaction of acyl chlorides using a scavenging resin
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A simple, efficient and fast method for the preparation of acyl halides from fatty carboxylic acids using a solid phase scavenging approach is presented herein. The title compounds can then be isolated, used as a solution or react in one-pot to form esters and amides with good to excellent yields.
- Girard,Tranchant,Niore,Herscovici
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p. 1577 - 1580
(2007/10/03)
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- THE DIRECT CONVERSION OF CARBOXYLIC ACIDS TO CARBOXAMIDES VIA REACTION WITH UNSOLVATED BIS(DIORGANOAMINO) MAGNESIUM REAGENTS
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It has been found that unsolvated bis(diorganoamino) magnesium compounds react smoothly with carboxylic acids to give the corresponding carboxamides directly in good to excellent yields.
- Sanchez, Ramiro,Vest, Gary,Despres, Lisa
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p. 2909 - 2914
(2007/10/02)
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