33544-42-2

Basic information

• Product Name: 4-HYDRAZINO-3-NITROPYRIDINE
• Synonyms: PYRIDINE, 4-HYDRAZINO-3-NITRO-;4-HYDRAZINO-3-NITROPYRIDINE;(3-nitropyridin-4-yl)hydrazine
• CAS NO: 33544-42-2
• Molecular Formula: C₅H₆N₄O₂
• Molecular Weight: 154.13
• EINECS: 125-856-9
• Mol File: 33544-42-2.mol

Chemical Properties

• Melting Point: 200 °C
• Boiling Point: 341 °C at 760 mmHg
• Flash Point: 160 °C
• Appearance: /
• Density: 1.524 g/cm³
• Vapor Pressure: 8.28E-05mmHg at 25°C
• Refractive Index: 1.707
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 4.17±0.36(Predicted)
• CAS DataBase Reference: 4-HYDRAZINO-3-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDRAZINO-3-NITROPYRIDINE(33544-42-2)
• EPA Substance Registry System: 4-HYDRAZINO-3-NITROPYRIDINE(33544-42-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 33544-42-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-HYDRAZINO-3-NITROPYRIDINE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 4-HYDRAZINO-3-NITROPYRIDINE serves as an intermediate in the production of agrochemicals, aiding in the creation of substances that protect crops and enhance agricultural productivity.
Used in Dye and Pigment Production:
4-HYDRAZINO-3-NITROPYRIDINE is utilized as a component in the manufacturing process of dyes and pigments, playing a role in the coloration of various products and materials.
Used in Research and Development:
4-HYDRAZINO-3-NITROPYRIDINE is employed in research and development laboratories for exploring its potential applications in the fields of medicine and agriculture, where it may contribute to advancements in these sectors.

InChI:InChI=1/C5H6N4O2/c6-8-4-1-2-7-3-5(4)9(10)11/h1-3H,6H2,(H,7,8)

Upstream product

• 31872-62-5 4-methoxy-3-nitro-pyridine 
• 5435-54-1 4-hydroxy-3-nitropyridine 

Downstream Products

• 1092790-41-4 1-(3-nitropyridin-4-yl)-5-aminopyrazole-4-carbonitrile 
• 121845-43-0 2-(3-amino-4-pyridinyl)-4-(trifluoromethyl)benzoic acid hydrazide hydrochloride 
• 121845-44-1 3-<4-(trifluoromethyl)phenyl>-1,2-dihydropyrido<3,4-e>-1,2,4-triazine hydrochloride 
• 121845-87-2 3-ethyl-1,2,3,4-tetrahydro-3-(phenylmethyl)pyrido<3,4-e>-1,2,4-triazine hydrochloride 
• 121845-59-8 3-[4-(trifluoromethyl)phenyl]pyrido[3,4-e]-1,2,4-triazine 

Relevant articles and documents

Comparison of the effects of 5- and 6-HOAt on model peptide coupling reactions relative to the cases for the 4- and 7-isomers

(equation presented) Synthesis of 5- and 6-HOAt has completed the full set of the four HOAt isomers derived from HOBt by insertion of a single nitrogen atom in the benzenoid nucleus. Comparison of the reactivity of all four isomers in model peptide coupling reactions has confirmed the unique character of the 7-isomer in promoting selectivity and maintaining configuration at the reactive carboxylic acid residue.

Pyrido[3,4-e]-1,2,4-triazines and related heterocycles as potential antifungal agents

The preparation and biological activities of a series of pyrido[3,4-e]-1,2,4-triazines, 1,2,4-triazino[5,6-c]quinolines, and related fused triazines are described. Methyl, amino, and acylamino substituents were placed in the pyridyl ring of the former system. Other structural modifications included various alkyl, cycloalkyl, substituted phenyl, and heterocyclic groups in the 3-position of these ring systems. In agar dilution assays, actives in this series inhibited strains of Candida, Aspergillus, Mucor, and Trychophyton species at MIC's of ≤ 16 μg/mL.