Ammonium chloride-promoted four-component synthesis of pyrrolo[3,4-b] pyridin-5-one
A novel multicomponent synthesis of 5-aminooxazole starting from simple and readily available inputs is described. Thus, simply heating a methanol solution of an aldehyde 3, an amine 4, and an α-isocyanoacetamide 5 provided the 5-aminooxazole (1) in good
A five-component synthesis of hexasubstituted benzene
Seven functional groups are involved in a highly ordered five-component domino process, which leads to a biologically relevant polyheterocycle. In this one-pot transformation, the formation of seven chemical bonds provides a hexasubstituted benzene core (
Janvier, Pierre,Bienayme, Hugues,Zhu, Jieping
p. 4291 - 4294
(2007/10/03)
A novel multicomponent synthesis of polysubstituted 5-aminooxazole and its new scaffold-generating reaction to pyrrolo[3,4-b]pyridine
matrix presented A novel three-component synthesis of 5-amino oxazole (1) is reported. Its subsequent reaction with α,β-unsaturated acyl chloride leads to polysubstituted pyrrolopyridine (2). A triple domino process, acylation/IMDA/retro-Michael cycloreve