336113-57-6

Basic information

• Product Name: (R)-2-(1-aMino-2-Methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one
• Synonyms: (R)-2-(1-aMino-2-Methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one;(R)-2-(1-Amino-2-methylpropyl)-3-benzyl-7-chloro-3H-quinazolin-4-one
• CAS NO: 336113-57-6
• Molecular Formula: C₁₉H₂₀ClN₃O
• Molecular Weight: 341.8346
• Mol File: 336113-57-6.mol

Chemical Properties

• Boiling Point: 510.9±60.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• PKA: 8.29±0.33(Predicted)
• CAS DataBase Reference: (R)-2-(1-aMino-2-Methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(1-aMino-2-Methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one(336113-57-6)
• EPA Substance Registry System: (R)-2-(1-aMino-2-Methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one(336113-57-6)

Safety Data

• Hazardous Substances Data: 336113-57-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-(1-aMino-2-Methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one is used as a potential pharmaceutical candidate for [application reason] due to its unique chemical structure and potential biological activities. (R)-2-(1-aMino-2-Methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one's specific application within the pharmaceutical industry may include areas such as drug development, targeting specific diseases, or enhancing the efficacy of existing medications.
Used in Research and Development:
In the field of research and development, (R)-2-(1-aMino-2-Methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one serves as a valuable compound for studying its biological activities and potential therapeutic effects. It may be utilized in various experimental setups to explore its interactions with biological targets, such as enzymes, receptors, or cellular pathways, which could lead to the discovery of novel treatments or a better understanding of certain diseases.

Upstream product

• 336119-88-1 (±)-2-(1-amino-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one 
• 887636-73-9 C₁₂H₁₄ClNO₃ 
• 108-12-3 isopentanoyl chloride 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 587881-25-2 (±)-2-(1-azido-2-methylpropyl)-3-benzyl-7-chloroquinazolin-4(3H)-one 
• 587881-24-1 (±)-3-benzyl-2-(1-bromo-2-methylpropyl)-7-chloroquinazolin-4(3H)-one 
• 587881-23-0 3-benzyl-7-chloro-2-(2-methylpropyl)-3,4-dihydroquinazolin-4-one 
• 587881-22-9 7-chloro-2-isobutyl-4H-benzo[d][1,3]oxazin-4-one 

Downstream Products

• 1417617-10-7 tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-2-fluorobenzamido)propyl)carbamate 
• 1417617-12-9 tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-nitrobenzamido)propyl)carbamate 
• 336113-53-2 (R)-ispinesib 
• 1417617-15-2 C₂₉H₃₀ClFN₄O₂ 
• 1417617-18-5 N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-3-fluorobenzamide 
• 1417617-04-9 (R)-tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-fluorobenzamido)propyl)carbamate 
• 1417617-21-0 C₂₉H₃₀ClFN₄O₂ 
• 587881-28-5 tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamido)propyl)carbamate 
• 1417617-07-2 tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-3-fluorobenzamido)propyl)carbamate 
• 1417617-24-3 C₂₉H₂₇ClF₃N₃O₃ 

Relevant articles and documents

Oxidative radical skeletal rearrangement induced by molecular oxygen: Synthesis of quinazolinones

Oxidative skeletal rearrangement of 5-aryl-4,5-dihydro-1,2,4-oxadiazoles into quinazolinones is induced by molecular oxygen (under a dry air atmosphere) that likely proceeds via transient iminyl radical species. Concise syntheses of biologically active qu

Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression

Anti-mitotic anti-cancer drugs offer a potential platform for developing new radiotracers for imaging proliferation markers associated with the mitosis-phase of the cell-cycle. One interesting target is kinesin spindle protein (KSP) - an ATP-dependent motor protein that plays a vital role in bipolar spindle formation. In this work we synthesised a range of new fluorinated-quinazolinone compounds based on the structure of the clinical candidate KSP inhibitor, ispinesib, and investigated their properties in vitro as potential anti-mitotic agents targeting KSP expression. Anti-proliferation (MTT and BrdU) assays combined with additional studies including fluorescence-assisted cell sorting (FACS) analysis of cell-cycle arrest confirmed the mechanism and potency of these biphenyl compounds in a range of human cancer cell lines. Additional studies using confocal fluorescence microscopy showed that these compounds induce M-phase arrest via monoaster spindle formation. Structural studies revealed that compound 20-(R) is the most potent fluorinated-quinazolinone inhibitor of KSP and represents a suitable lead candidate for further studies on designing 18F-radiolabelled agents for positron-emission tomography (PET).