- Sulfamides and Sulfonamides as Polar Aprotic Solvents
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Five tetraalkylsulfamides, one N,N-dialkylsulfonamide, two sulfurous diamides, and one sulfinamide were investigated for potential use as polar aprotic solvents that would be compatible with strongly basic and nucleophilic reagents.The values of Taft β and ?* measured for these compounds indicated that all possess significant polar aprotic solvent character.Their stabilities toward ethylmagnesium bromide, diethylzinc, methyllithium, and butyllithium were determined.Tetraethylsulfamide (Et2NSO2NEt2) and N,N-diethyltrimethylmethanesulfonamide (Me3CSO2NEt2) were the most stable of the solvents, showing no evidence of decomposition with the magnesium or zinc compounds and an appreciable lifetime with methyllithium.
- Richey, Herman G.,Farkas, Julius
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- Reactions of sulfites with secondary amines 1. Diphenyl and alkyl phenyl sulfites
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The interaction or diethylamine and morpholine with diphenyl, methyl phenyl, ethyl phenyl, and isopropyl phenyl sulfites was studied. It was established that two reactions, substitution and alkylation, can occur in parallel. Diphenyl sulfites react with amines to give only substitution products, while other sulfites react with substitution at the sulfur atom and with alkylation of the amines.
- Badeev,Ivanov,Naumova
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- Synthesis, biological evaluation and molecular modeling of substituted indeno[1,2-b]indoles as inhibitors of human protein kinase CK2
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Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked great interest for the design of ATP-competitive inhibitors of human CK2. In the present study, we prepared twenty-one indeno[1,2-b]indole derivatives, all of which were tested in vitro on human CK2. The indenoindolones 5a and 5b inhibited human CK2 with an IC50 of 0.17 and 0.61 μM, respectively. The indeno[1,2-b]indoloquinone 7a also showed inhibitory activity on CK2 at a submicromolar range (IC50 = 0.43 μM). Additionally, a large number of indenoindole derivatives was evaluated for their cytotoxic activities against the cell lines 3T3, WI-38, HEK293T and MEF.
- Alchab, Faten,Ettouati, Laurent,Bouaziz, Zouhair,Bollacke, Andre,Delcros, Jean-Guy,Gertzen, Christoph G. W.,Gohlke, Holger,Pinaud, No?l,Marchivie, Mathieu,Guillon, Jean,Fenet, Bernard,Jose, Joachim,Le Borgne, Marc
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p. 279 - 302
(2015/06/30)
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- Reactions of sulfenamides and N,N′-thiobisamines with Tert-butyl hypochlorite
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Reactions of sulfenamides R′SNR2 and N,N′-thiobisamines R2NSNR2 with tert-butyl hypochlorite in the presence of triethylamine yield sulfinamides R′S(O)NR2 and N,N′-sulfinylbisamines R2NS(O)NR2.
- Musin
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p. 798 - 800
(2007/10/03)
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