METHODS FOR SELECTIVE AROMATIZATION OF CANNABINOIDS
The present invention relates to methods of selective aromatization of cannabinoids. Such methods may be used, among other purposes, for the removal of delta-9-tetrahydrocannabinol from hemp extracts or other samples by selectively converting delta-9-tetrahydrocannabinol to cannabinol using ortho-quinone catalysts.
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Paragraph 0070-0072
(2022/02/11)
One-Pot Total Synthesis of Cannabinol via Iodine-Mediated Deconstructive Annulation
The thermal degradation of cannabichromene (CBC, 3) is dominated by cationic reactions and not by the pericyclic rearrangements observed in model compounds. The rationalization of these differences inspired the development of a process that coupled, in an aromatization-driven single operational step, the condensation of citral and alkylresorciniols to homoprenylchromenes and their in situ deconstructive annulation to benzo[c]chromenes. This process was applied to a total synthesis of cannabinol (CBN, 5) and to its molecular editing.
Caprioglio, Diego,Mattoteia, Daiana,Minassi, Alberto,Pollastro, Federica,Lopatriello, Annalisa,Muňoz, Eduardo,Taglialatela-Scafati, Orazio,Appendino, Giovanni
p. 6122 - 6125
(2019/08/20)
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