- Synthesis method of acetal compound of 3-halogenated propionaldehyde
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The invention discloses an acetal compound of 3-halogenated propionaldehyde, which has a general formula shown in the specification. The synthesis method comprises the following steps: reacting an alcohol compound with an acrolein compound at -10-40 DEG C under the action of a halide or derivative of boron, silicon, sulfur or phosphorus and an initiator thereof to generate the acetal compound of 3-halogenated propionaldehyde; wherein the alcohol compound comprises monohydric alcohol or dihydric alcohol, and the halogenation refers to F, Cl, Br or I substitution; the acrolein compound has a general formula I shown in the specification, wherein R1, R2, R3, R4, R5, R6 and R7 are selected from hydrogen atoms, various alkyl groups or various aryl groups. According to the invention, the acetal compound of 3-halogenated propionaldehyde is synthesized from the halide or derivative of boron, silicon, sulfur or phosphorus, the acrolein compound and the alcohol compound by a one-pot method. Compared with a synthesis method in the prior art, the method has the advantages that the technological process is simpler, and the yield of a target product is higher.
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Paragraph 0066-0073
(2020/05/14)
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- Preparation and properties of a novel solution of hydrogen bromide (HBr) in 1,4-dioxane: An alternative reagent to HBr gas without protic solvents
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A solution of hydrogen bromide (HBr) in 1,4-dioxane was prepared and investigated for its ability to brominate alcohols, and hydrobrominate alkenes. This study revealed that the brominating ability of this HBr/1,4-dioxane solution is equal or superior to that of hydrobromic acid or HBr in acetic acid. The solution of HBr in 1,4-dioxane is robust, exhibiting no decomposition of the solvent, and retaining 97% of its original concentration, when kept at ?25 °C for 30 days. This solution is a liquid alternative to HBr gas without protic solvents.
- Nishio, Yuya,Mifune, Ryota,Sato, Taisuke,Ishikawa, Shin-ich,Matsubara, Hiroshi
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p. 1190 - 1193
(2017/03/02)
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- METHOD FOR PRODUCING BROMINE-CONTAINING CYCLIC ACETAL COMPOUND
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PROBLEM TO BE SOLVED: To provide a method for producing a bromine-containing cyclic acetal compound with high efficiency and high yields and, additionally, provide a highly safe and inexpensive production method. SOLUTION: A bromine-containing cyclic acetal compound is obtained with high yields by the reaction of an α,β-unsaturated carbonyl compound, hydrogen bromide and ethylene glycol in coexistence of ether. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
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Paragraph 0039; 0040; 0042
(2017/06/24)
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- The Preparation of Some β-Sulfonylacrylate Thioesters and β-Sulfonylvinyl Ketones
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β-Sulfonylacrylate phenyl and t-butyl thioesters, and β-sulfonylvinyl ketones have been prepared by oxidation of the corresponding β-aryl- and β-alkyl-thio compounds.In one case the β-sulfonylvinyl ketone was obtained from an epoxy sulfone.The β-aryl- and β-alkyl-thio compounds were obtained by chlorination-dehydrochlorination of saturated precursors.The reactions of 3-(phenylthio)propionyl chloride with organocadmium and Grignard reagents were used to prepare some of the saturated precursors of the β-sulfonylvinyl ketones.
- Haynes, Richard K.,Vonwiller, Simone C.,Stokes, John P.,Merlino, Louisa M.
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p. 881 - 895
(2007/10/02)
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- A READY PREPARATION OF 2-(2-IODOETHYL)-1,3-DIOXANE: A FACILE THREE- CARBON EXTENSION OF GRIGNARD REAGENTS.
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A rapid preparation of the title compound in essentially pure form upon solvent removal and its reaction with Grignard reagents in the presence of copper (I) is reported.
- Lee, Yuh-Shan,Valle ,Luis del,Larson, Gerald L.
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p. 385 - 392
(2007/10/02)
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- Jasmonoid Synthesis from cis-4-Heptenoic Acid
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Jesmonoids with cis-2-pentenyl side-chain such as cis-jasmone, methyl jasmonate, and jasmolone were easily synthesized from cis-4-heptenoic acid obtained by the ring opening reaction of β-propiolactone with di-cis-butenylcuprate.
- Sato, Toshio,Kawara, Tatsuo,Sakata, Kazumi,Fujisawa, Tamotsu
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p. 505 - 508
(2007/10/02)
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- REACTIVITE DES DERIVES DE CYCLOPROPYLIDENE-3 PROPYLE-I. SYNTHESE D'ALCOOLS β-CYCLOPROPYLIDENIQUES
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A series of β-cyclopropylidenic alcohols has been synthesized through the following sequence:(i) Wittig condensation between cyclopropylidenetriphenylphosphorane with appropriate monoprotected 1,3-dicarbonyl compounds; (ii)smooth hydrolysis of acetals (after necessary transacetalization step) and ketals thus formed; (iii) LAH reduction of aldehydes and ketones(yielding primary and secondery alcohols respectively) or treatment of ketones with methyllithium (yielding tertiary alcohols).
- Bertrand, M.,Leandri, G.,Meou, A.
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p. 1703 - 1710
(2007/10/02)
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- Novel prostaglandin derivatives of the Δ2-PGF2 and Δ2-PGE2 series and process for their manufacture
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What is disclosed are compounds of the formula STR1 which are structurally related to natural prostaglandins and a process for their manufacture. The compounds have valuable pharamacological properties and, therefore, they can be used as medicaments.
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