340-52-3

Basic information

• Product Name: nitromethaqualone
• Synonyms: nitromethaqualone;3-(2-Methoxy-4-nitrophenyl)-2-methyl-4(3H)-quinazolinone;3-(2-Methoxy-4-nitrophenyl)-2-methylquinazolin-4(3H)-one;CHI-26;Parnox;Nitromethaqualone ada@tuskwei.com whatsapp
• CAS NO: 340-52-3
• Molecular Formula: C₁₆H₁₃N₃O₄
• Molecular Weight: 311.2921
• Product Categories: Nitromethaqualone ada@tuskwei.com whatsapp;+8618031153937
• Mol File: 340-52-3.mol

Chemical Properties

• Boiling Point: 528°Cat760mmHg
• Flash Point: 273.1°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 3.1E-11mmHg at 25°C
• Refractive Index: 1.651
• CAS DataBase Reference: nitromethaqualone(CAS DataBase Reference)
• NIST Chemistry Reference: nitromethaqualone(340-52-3)
• EPA Substance Registry System: nitromethaqualone(340-52-3)

Safety Data

• Hazardous Substances Data: 340-52-3(Hazardous Substances Data)

Usage

Uses

Used in Research Applications:
Nitromethaqualone is used as a research compound for the development and validation of new analytical methods and techniques in the field of chemistry and pharmacology. Its unique structure allows researchers to study its interactions with various biological systems and explore its potential applications in drug discovery.
Used in Forensic Applications:
In forensic science, nitromethaqualone is used as a reference standard for the identification and quantification of similar compounds in criminal investigations. Its distinct chemical properties make it a valuable tool for forensic analysts to accurately determine the presence and concentration of related substances in evidence samples.

InChI:InChI=1/C16H13N3O4/c1-10-17-13-6-4-3-5-12(13)16(20)18(10)14-8-7-11(19(21)22)9-15(14)23-2/h3-9H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 83759-26-6 2-methyl-3-(2'-hydroxy-4'-nitrophenyl)-4(3H)-quinazolinone 
• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 97-52-9 2-methoxy-4-nitrophenylamine 
• 89-52-1 o-acetylamino-benzoic acid 
• 121-88-0 5-Nitro-2-aminophenol 

Downstream Products

• 74674-70-7 2-methyl-3-(2'-methoxy-4'-aminophenyl)-4(3H)-quinazolinone 
• 105271-37-2 2-methyl-3-(2-methoxy-4-(3-chlorophenyl)thiocarbamidophenyl)-4-quinazolone 
• 105271-29-2 2-methyl-3-(2-methoxy-4-(4-methoxyphenyl)thiocarbamidophenyl)-4-quinazolone 
• 105271-21-4 2-methyl-3-(2-methoxy-4-(4-tolyl)thiocarbamidophenyl)-4-quinazolone 

Relevant articles and documents

Biotransformation and excretion of nitromethaqualone in rats and humans

The metabolic disposition of 14C-labeled nitromethaqualone was investigated in rats. Unlabeled nitromethaqualone was used for studies on humans. Nitromethaqualone was eliminated from the body after most of it had undergone biotransformation. Both humans and rats reduced the nitro group of nitromethaqualone to the corresponding amino derivative, which was partially transformed to the corresponding acetylated form. Cleavage of the quinazolinone nucleus resulting in 2-methoxy-4-nitroaniline was also observed in humans. In rats additional major metabolites arose from the oxidation of the 2-methyl group into hydroxymethyl resulting in 2-hydroxymethyl-3-(2'-methoxy-4'-nitrophenyl)-4(3H)-quinazolinone and concomitant in vivo reduction of the latter resulting in 2-hydroxymethyl-3-(2'-methoxy-4'-aminophenyl)-4(3H)-quinazolinone. Both metabolites were also excreted as glucuronides. In rats fecal excretion accounted for 55-60% of the administered dose, while 24-27% was excreted in the urine. Protracted excretion in both humans and rats indicated an extensive enterohepatic circulation.