340256-29-3Relevant articles and documents
Stereodivergent Synthesis of Tertiary Fluoride-Tethered Allenes via Copper and Palladium Dual Catalysis
Yang, Shao-Qian,Wang, Yi-Fan,Zhao, Wei-Cheng,Lin, Guo-Qiang,He, Zhi-Tao
supporting information, p. 7285 - 7291 (2021/05/26)
Herein we describe a protocol for the unprecedented stereodivergent synthesis of tertiary fluoride-tethered allenes bearing a stereogenic center and stereogenic axis via Cu/Pd synergistic catalysis. A broad scope of conjugated enynes are coupled with various α-fluoroesters in high yields with high diastereoselectivities and generally >99% ee. In addition, the four stereoisomers of the allene products ensure precise access to the corresponding four stereoisomers of the fluorinated hydrofurans via a novel stereodivergent axial-to-central chirality transfer process.
Gold catalyzed efficient preparation of dihydrobenzofuran from 1,3-enyne and phenol
Wang, Yu-Jiang,Zhang, Yuan,Qiang, Zou,Liang, Jia-Ying,Chen, Zili
supporting information, p. 12607 - 12610 (2021/12/07)
A gold catalyzed formal intermolecular [2+3] cyclo-coupling of 1,3-enynes with phenols was developed to prepare dihydrobenzofuran derivatives with the addition of 2,6-dichloropyridine N-oxide, in which, a highly ortho-selective phenol SEAr functionalizati
Enantioselective Synthesis of Multisubstituted Allenes by Cooperative Cu/Pd-Catalyzed 1,4-Arylboration of 1,3-Enynes
Liao, Yang,Yin, Xuemei,Wang, Xihong,Yu, Wangzhi,Fang, Dongmei,Hu, Lianrui,Wang, Min,Liao, Jian
supporting information, p. 1176 - 1180 (2019/12/11)
A cooperative Cu/Pd-catalyzed enantioselective synthesis of multisubstituted allenes is established. By employing chiral sulfoxide phosphine (SOP)/Cu and PdCl2(dppf) complexes as catalysts, the 1,4-arylboration of 1,3-enynes provides an efficient approach to trisubstituted chiral allenes with up to 92 % yield and 97:3 er. Furthermore, by using 2-substituted 1,3-enynes as substrates, the tetrasubstituted chiral allenes were successfully generated using this strategy. Finally, theoretical calculations indicate that the transmetallation of the allenylcopper species is the rate-limiting step of this transformation.
Triple-Bond Insertion Triggers Highly Regioselective 1,4-Aminomethylamination of 1,3-Enynes with Aminals Enabled by Pd-Catalyzed C-N Bond Activation
Zhang, Yanchen,Yu, Bangkui,Gao, Binjian,Zhang, Tianze,Huang, Hanmin
supporting information, (2019/01/21)
A highly chemo- and regioselective 1,4-aminomethylamination of simple enynes with aminals to allenic 1,5-diamines by taking advantage of C-N bond activation has been reported. The reaction proceeds under mild reaction conditions and can be performed under
Triple-Bond Insertion Triggers Highly Regioselective 1,4-Aminomethylamination of 1,3-Enynes with Aminals Enabled by Pd-Catalyzed C-N Bond Activation
Zhang, Yanchen,Yu, Bangkui,Gao, Binjian,Zhang, Tianze,Huang, Hanmin
supporting information, p. 535 - 539 (2019/01/24)
A highly chemo- and regioselective 1,4-aminomethylamination of simple enynes with aminals to allenic 1,5-diamines by taking advantage of C-N bond activation has been reported. The reaction proceeds under mild reaction conditions and can be performed under
Copper- and cobalt-catalyzed direct coupling of sp3 α-carbon of alcohols with alkenes and hydroperoxides
Cheng, Jun-Kee,Loh, Teck-Peng
supporting information, p. 42 - 45 (2015/01/30)
A zerovalent copper- and cobalt-catalyzed direct coupling of the sp3 α-carbon of alcohols with alkenes and hydroperoxides was developed in which the hydroperoxides acted as radical initiator and then coupling partner. 1,3-Enynes and vinylarenes
