340268-50-0

Basic information

• Product Name: 1H-Cyclopenta[c]pyridine-1,6(2H)-dione,5-ethyl-5,7-dihydro-5-hydroxy-(9CI)
• Synonyms: 1H-Cyclopenta[c]pyridine-1,6(2H)-dione,5-ethyl-5,7-dihydro-5-hydroxy-(9CI)
• CAS NO: 340268-50-0
• Molecular Formula: C10H11NO3
• Molecular Weight: 193.19924
• Product Categories: CYCLOPENTANE
• Mol File: 340268-50-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Cyclopenta[c]pyridine-1,6(2H)-dione,5-ethyl-5,7-dihydro-5-hydroxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Cyclopenta[c]pyridine-1,6(2H)-dione,5-ethyl-5,7-dihydro-5-hydroxy-(9CI)(340268-50-0)
• EPA Substance Registry System: 1H-Cyclopenta[c]pyridine-1,6(2H)-dione,5-ethyl-5,7-dihydro-5-hydroxy-(9CI)(340268-50-0)

Safety Data

• Hazardous Substances Data: 340268-50-0(Hazardous Substances Data)

Relevant articles and documents

Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin

Ten novel camptothecin (CPT) derivatives devoid of the lactone function in the E-ring were synthesized and evaluated as anticancer agents. Several of these CPT analogues bearing a five-membered E-ring are potent inhibitors of the DNA relaxation and cleavage reactions catalyzed by topoisomerase I and exhibit promising cytotoxic activities with IC50 values in the nM range. This is the first successful design of lactone-free CPT, providing thus a new avenue to the development of topoisomerase I targeted antitumor agents.